Jiayun Ge, Zhihong Zhang, Guohui Shao, Dong Wei, Bo Tang, Zhitian Shi, Renchao Zou, Xin Wang
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引用次数: 0
Abstract
miR-145-5p regulates drug sensitivity in various cancer types and is also expressed at significantly low levels in pancreatic cancer (PC), but its role in PC resistance to gemcitabine is not yet clear. This study revealed low expression of miR-145-5p in the PC gemcitabine-resistant cell lines SW1990/GEM and PANC-1/GEM. The overexpression of miR-145-5p inhibited the proliferation and migration of PC drug-resistant cells. Mechanistically, miR-145-5p overexpression increased the sensitivity of PC drug-resistant cells to gemcitabine through the inhibition of CDCA3, thereby inhibiting the proliferation and migration of PC drug-resistant cells. Our study indicated that the upregulation of miR-145-5p expression might be an effective target for improving the treatment efficacy of PC.
期刊介绍：
General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.
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