Effect of exposure to ambient air volatile organic compounds on the severity of atopic dermatitis and lag-day effect.

IF 2.3 4区 医学 Q3 ALLERGY
Hui-Wen Tseng
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引用次数: 0

Abstract

Background: Previous studies reported positive associations between exposure to air volatile organic compounds (VOCs) and daily visits for atopic dermatitis (AD).

Objective: This population-based study investigated associations between air VOCs exposure and daily hospitals visits for AD, severity subgroup (mild and severe), and lag-day effect in central-southern Taiwan.

Methods: The dependent variable was AD with diagnostic codes (ICD-9-CM 691.8 and ICD-10-CM L20) retrieved from the Taiwan National Health Insurance Research Database from 2008/01/01 to 2018/12/31. Independent variables included one-day 75th-percentile value of each VOC (benzene, ethylbenzene, toluene, m-/p-xylene, o-xylene, 1,3,5-trimethylbenzene, 1,2,4-trimethylbenzene, isopentane, n-pentane, n-hexane, methylcyclohexane, and cyclohexane) and four meteorological conditions from the Taiwan Air Quality Monitoring Network Database. This was a case-crossover design with multivariable conditional logistic regression, and the adjusted odds ratios (AORs) were reported.

Results: Concentrations of the 12 air VOCs significantly positively affected the total number of daily visits for AD (AOR = 1.02~1.69, P < 0.001) and subgroups of mild (AOR = 1.001~1.049, P < 0.001) and severe (AOR = 1.002~1.077, P < 0.001). The effect of air VOCs on the severe AD group was higher than that on the mild group. Values of the six VOCs on the 1st lag day (benzene: AOR = 1.16, 1,3,5-trimethylbenzene: AOR = 1.5, 1,2,4-trimethylbenzene: AOR = 1.13, isopentane: AOR = 1.07, n-pentane: AOR = 1.08, methylcyclohexane: AOR = 1.5, all P < 0.05) were significantly positively associated with the number of daily visits for AD.

Conclusions: Exposure to the 12 air VOCs on the visit days increased the risks of daily visits for AD in total and severity subgroup. The effects of six certain VOCs on the 1st lag day were significant positive.

暴露于环境空气中挥发性有机化合物对特应性皮炎严重程度的影响及滞后效应。
背景:先前的研究报告了空气挥发性有机化合物(VOCs)暴露与特应性皮炎(AD)的日常就诊之间的正相关。目的:本研究以人群为基础,探讨台湾中南部地区空气中挥发性有机化合物暴露与阿尔茨海默病患者每日医院就诊次数、严重程度亚组(轻度和重度)及滞后效应的关系。方法:因变量为AD,诊断代码为ICD-9-CM 691.8和ICD-10-CM L20,检索自台湾全民健康保险研究数据库(2008/01/01 - 2018/12/31)。自变量包括当天各挥发性有机化合物(苯、乙苯、甲苯、间/对二甲苯、邻二甲苯、1,3,5-三甲苯、1,2,4-三甲苯、异戊烷、正戊烷、正己烷、甲基环己烷和环己烷)的75百分位值以及台湾省空气质量监测网络数据库中的4种气象条件。本研究采用病例交叉设计,采用多变量条件逻辑回归,并报告校正优势比(AORs)。结果:空气中12种VOCs浓度对AD日总就诊次数(AOR = 1.02~1.69, P < 0.001)、轻度亚组(AOR = 1.001~1.049, P < 0.001)和重度亚组(AOR = 1.002~1.077, P < 0.001)均有显著正相关影响。空气中VOCs对重度AD组的影响高于轻度AD组。滞后第1天6种挥发性有机化合物(苯:AOR = 1.16, 1,3,5-三甲基苯:AOR = 1.5, 1,2,4-三甲基苯:AOR = 1.13,异戊烷:AOR = 1.07,正戊烷:AOR = 1.08,甲基环己烷:AOR = 1.5, P均< 0.05)与AD日访问量呈显著正相关。结论:在就诊日暴露于12种空气挥发性有机化合物增加了AD总和严重程度亚组的每日就诊风险。6种VOCs在滞后第1天的影响显著为正。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
74
审稿时长
>12 weeks
期刊介绍: The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.
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