Mortality With Impella Is Lowest in Overweight and Obese but Is Highest in Morbid Obesity.

IF 2.2 3区医学 Q3 ENGINEERING, BIOMEDICAL

Artificial organs Pub Date : 2025-03-21 DOI:10.1111/aor.15000

Mohammad Reza Movahed, Spencer Bradshaw, Mehrtash Hashemzadeh

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引用次数: 0

Abstract

Introduction: Mortality of cardiogenic shock remains high, prompting increased use of mechanical circulatory support devices such as Impella. This study sought to characterize whether weight categories predict mortality in patients who received Impella devices.

Methods: We used data from the National Inpatient Sample (NIS) database from the years 2016 to 2020 and ICD-10-CM/PCS codes to evaluate the effect of weight categories on mortality in patients undergoing Impella implantation.

Results: A total of 86 810 patients underwent Impella device implantation, with an overall mortality of 29.85%. Mortality for normal weight was 30.4%, similar to cachexia (30.3%) and morbidly obese patients (31.1%). However, the overweight and obese categories had the lowest mortality (13.4% and 24.9%, p < 0.0001). Using multivariate analysis adjusting for comorbid conditions, overweight and obesity remained significantly associated with the lowest mortality (overweight: OR: 0.3, CI: 0.16-0.68, p = 0.003, Obese: OR: 0.8, CI: 0.71-0.91, p < 001) whereas morbid obesity was associated with the highest mortality (OR: 1.17, CI: 1.02-1.34, p = 0.02).

Conclusion: Using a large database, we found that overweight and obesity have a protective effect on mortality in patients undergoing Impella insertion. However, morbid obesity appears to have detrimental effects.

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来源期刊

Artificial organs 工程技术-工程：生物医学

CiteScore

4.30

自引率

12.50%

发文量

303

审稿时长

4-8 weeks

期刊介绍： Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.