Mathematical Modelling of the First HIV/ZIKV Co-infection Cases in Colombia and Brazil.

IF 2 4区 数学 Q2 BIOLOGY
Jhoana P Romero-Leiton, Idriss Sekkak, Julien Arino, Iain Moyles, Bouchra Nasri
{"title":"Mathematical Modelling of the First HIV/ZIKV Co-infection Cases in Colombia and Brazil.","authors":"Jhoana P Romero-Leiton, Idriss Sekkak, Julien Arino, Iain Moyles, Bouchra Nasri","doi":"10.1007/s11538-025-01429-x","DOIUrl":null,"url":null,"abstract":"<p><p>This paper presents a mathematical model to investigate the co-infection with human immunodeficiency virus (HIV) and Zika virus (ZIKV) in Colombia and Brazil, where the first cases were reported in 2015. The model considers the sexual transmission dynamics of both viruses and vector-host interactions. We begin by exploring the qualitative behaviour of each model separately. We then analyze the dynamics of the co-infection model using the thresholds and results defined separately for each model. The model also considers the impact of intervention strategies, such as personal protection, antiretroviral therapy (ART), and sexual protection (condom use). Using available and assumed parameter values for Colombia and Brazil, the model is calibrated to investigate the long-term co-infection dynamics, the influence of specific parameters, and the potential effect of implementing these intervention strategies on co-infection spread. The study's results revealed that the duration of Zika infection is a critical factor influencing the burden of co-infection cases. Additionally, bed nets and use of condoms are essential for disease control, while ART is less emphasized due to the cost-effectiveness of condom use.</p>","PeriodicalId":9372,"journal":{"name":"Bulletin of Mathematical Biology","volume":"87 5","pages":"54"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Mathematical Biology","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1007/s11538-025-01429-x","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

This paper presents a mathematical model to investigate the co-infection with human immunodeficiency virus (HIV) and Zika virus (ZIKV) in Colombia and Brazil, where the first cases were reported in 2015. The model considers the sexual transmission dynamics of both viruses and vector-host interactions. We begin by exploring the qualitative behaviour of each model separately. We then analyze the dynamics of the co-infection model using the thresholds and results defined separately for each model. The model also considers the impact of intervention strategies, such as personal protection, antiretroviral therapy (ART), and sexual protection (condom use). Using available and assumed parameter values for Colombia and Brazil, the model is calibrated to investigate the long-term co-infection dynamics, the influence of specific parameters, and the potential effect of implementing these intervention strategies on co-infection spread. The study's results revealed that the duration of Zika infection is a critical factor influencing the burden of co-infection cases. Additionally, bed nets and use of condoms are essential for disease control, while ART is less emphasized due to the cost-effectiveness of condom use.

哥伦比亚和巴西首例艾滋病毒/寨卡病毒合并感染病例的数学模型
本文提出了一个数学模型,用于调查哥伦比亚和巴西的人类免疫缺陷病毒(HIV)和寨卡病毒(ZIKV)合并感染,这两个国家于2015年报告了第一例病例。该模型考虑了病毒和媒介-宿主相互作用的性传播动力学。我们首先分别探索每个模型的定性行为。然后,我们使用分别为每个模型定义的阈值和结果来分析共同感染模型的动态。该模型还考虑了干预策略的影响,如个人保护、抗逆转录病毒治疗(ART)和性保护(使用避孕套)。使用哥伦比亚和巴西的可用参数值和假设参数值,对模型进行校准,以研究长期共感染动态、特定参数的影响以及实施这些干预策略对共感染传播的潜在影响。研究结果表明,寨卡病毒感染的持续时间是影响合并感染病例负担的关键因素。此外,蚊帐和使用避孕套对疾病控制至关重要,而由于使用避孕套的成本效益,抗逆转录病毒治疗不太受重视。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.90
自引率
8.60%
发文量
123
审稿时长
7.5 months
期刊介绍: The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including: Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations Research in mathematical biology education Reviews Commentaries Perspectives, and contributions that discuss issues important to the profession All contributions are peer-reviewed.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信