The effects of β-TCP and/or xenogeneic bone substitute on alveolar ridge preservation: a randomized clinical trial.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2025-03-21 DOI:10.1007/s00784-025-06272-x

Liu Gao, Huilin Zhu, Yuqian Kou, Hongcheng Hu, Yuwei Wu, Zhihui Tang, Qing Li

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引用次数: 0

Abstract

Objectives: After tooth extraction, the alveolar ridge undergoes significant absorption, and the alveolar ridge preservation (ARP) will alleviate the complexity of implantation operations in specific clinical occasions and then improve the functionality and aesthetics of subsequent restoration. However, the effectiveness of β-tricalcium phosphate (β-TCP) composite materials for ARP needs to be confirmed by more clinical trials and more sufficient evidence. This study was aimed at evaluating the effects of β-TCP coating porous bovine deproteinization bone (β-TCP/PBDB) on ARP when compared with Bio-Oss^®.

Materials and methods: After baseline clinical examination, teeth extractions and the ARP were conducted randomly by β-TCP/PBDB or the Bio-Oss^®. A collagen sponge was applied over the bone substitutes. After 6 months, clinical examination and cone-beam computerized tomography (CBCT) imaging analysis were conducted to evaluate the changes in alveolar bone volume.

Results: In the clinical trial, a total of 123 patients successfully completed the protocol. The surgical socket and the soft tissues healed well. The reduction of alveolar ridge width was 1.27 ± 1.32 mm, 0.89 ± 1.31 mm, and 0.63 ± 1.37 mm at three levels (1 mm, 3 mm, 5 mm) below the crest of alveolar ridge respectively using β-TCP/PBDB, while those were 1.12 ± 1.65 mm, 0.55 ± 1.41 mm, 0.56 ± 1.32 mm respectively in the Bio-Oss^® group. The reduction of alveolar ridge height was 0.75 ± 1.96 mm in buccal and 0.95 ± 1.96 mm in lingual using β-TCP/PBDB while those were 1.01 ± 2.44 mm and 0.99 ± 2.13 mm respectively in the Bio-Oss^® group. There is no significant difference in the width and height changes of the alveolar ridge compared to Bio-Oss^® (p > 0.05).

Conclusions: This prospective, randomized, controlled clinical trial provided evidence that β-TCP/PBDB is a safe material and the effectiveness of β-TCP/PBDB in maintaining the volume and contour of the alveolar ridge is comparable to that of the Bio-Oss^® material.

Clinical relevance: The β-TCP/PBDB can be used as one option of bone substitute material for ARP.

查看原文本刊更多论文

β-TCP和/或异种骨替代物对牙槽嵴保存的影响：一项随机临床试验。

目的：拔牙后牙槽嵴吸收明显，牙槽嵴保存（ARP）可减轻临床特定情况下种植手术的复杂性，进而提高后续修复的功能性和美观性。然而，β-磷酸三钙（β-TCP）复合材料对ARP的有效性还需要更多的临床试验和更充分的证据来证实。本研究旨在评价β-TCP涂层多孔牛脱蛋白骨（β-TCP/PBDB）对ARP的影响，并与Bio-Oss®进行比较。材料和方法：临床基线检查后，随机采用β-TCP/PBDB或Bio-Oss®进行拔牙和ARP。将胶原蛋白海绵敷在骨替代物上。6个月后进行临床检查和锥形束计算机断层扫描（CBCT）成像分析，评估牙槽骨体积的变化。结果：在临床试验中，共有123例患者成功完成了该方案。手术窝和软组织愈合良好。β-TCP/PBDB组牙槽嵴嵴下1 mm、3 mm、5 mm三个水平的牙槽嵴宽度分别减少1.27±1.32 mm、0.89±1.31 mm、0.63±1.37 mm，而Bio-Oss®组牙槽嵴嵴下3个水平的牙槽嵴宽度分别减少1.12±1.65 mm、0.55±1.41 mm、0.56±1.32 mm。β-TCP/PBDB组颊部牙槽嵴高度降低0.75±1.96 mm，舌部牙槽嵴高度降低0.95±1.96 mm，而Bio-Oss®组牙槽嵴高度降低1.01±2.44 mm和0.99±2.13 mm。与Bio-Oss®相比，牙槽嵴宽度和高度变化无显著差异（p < 0.05）。结论：这项前瞻性、随机、对照临床试验证明β-TCP/PBDB是一种安全的材料，β-TCP/PBDB在维持牙槽嵴体积和轮廓方面的有效性与Bio-Oss®材料相当。临床意义：β-TCP/PBDB可作为ARP骨替代材料的一种选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.