The association between particulate matter 2.5 and thyroid function and thyroid cancer: a meta-analysis.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI:10.1007/s00420-025-02133-y

Haihong Wang, Jing Xu, Caizhu Huang, Lichao Chen, Xiandan Zhang, Wenjun Tian

{"title":"The association between particulate matter 2.5 and thyroid function and thyroid cancer: a meta-analysis.","authors":"Haihong Wang, Jing Xu, Caizhu Huang, Lichao Chen, Xiandan Zhang, Wenjun Tian","doi":"10.1007/s00420-025-02133-y","DOIUrl":null,"url":null,"abstract":"Purpose: Recent studies indicate a potential link between exposure to atmospheric particulate matter 2.5 (PM2.5) and thyroid function, though epidemiological conclusions remain inconsistent. This comprehensive systematic review and meta-analysis aims to clarify the connection between PM2.5 levels and the risks of thyroid function and thyroid cancer.Methods: Using the medical subject headings \"PM2.5\" and \"thyroid hormones\" along with their associated free words, publications from the Web of Science, Embase, Cochrane Library, and PubMed up to April 2024 were searched. The study protocol has been registered on PROSPERO (CRD42024554220).Results: A total of 1322 articles were collected from databases, of which 27 studies were included in the analysis. The findings indicated that exposure to PM2.5 was a significant risk factor for hypothyroidism, increasing the incidence risk by 0.15 (95% CI 1.08, 1.23, P < 0.001). PM2.5 exposure levels were significantly higher in Asian populations than in European populations; each incremental increase in PM2.5 exposure resulted in a rise in TSH by 0.27 mIU/L (95% CI 0.07, 0.47, P = 0.008) and a decrease in FT4 by 0.21 pmol/L (95% CI - .35, - 0.07, P = 0.004). Additionally, in susceptible pregnant women, each incremental increase in PM2.5 exposure during pregnancy was associated with a rise in TSH levels by 0.08 mIU/L (95% CI - 0.02, 0.17, P < 0.001) and a decrease in FT4 levels by 0.09 pmol/L (95% CI - 0.23, 0.05, P = 0.210).Conclusion: Our research establishes PM2.5 exposure as a risk factor for diminished thyroid function. In Asian populations, the average level of PM2.5 exposure is high, significantly affecting thyroid hormones (TSH, FT4). Particular attention to PM2.5 exposure levels during pregnancy is essential to reduce the risk of thyroid dysfunction.","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":" ","pages":"267-282"},"PeriodicalIF":2.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Archives of Occupational and Environmental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00420-025-02133-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Recent studies indicate a potential link between exposure to atmospheric particulate matter 2.5 (PM2.5) and thyroid function, though epidemiological conclusions remain inconsistent. This comprehensive systematic review and meta-analysis aims to clarify the connection between PM2.5 levels and the risks of thyroid function and thyroid cancer.

Methods: Using the medical subject headings "PM2.5" and "thyroid hormones" along with their associated free words, publications from the Web of Science, Embase, Cochrane Library, and PubMed up to April 2024 were searched. The study protocol has been registered on PROSPERO (CRD42024554220).

Results: A total of 1322 articles were collected from databases, of which 27 studies were included in the analysis. The findings indicated that exposure to PM2.5 was a significant risk factor for hypothyroidism, increasing the incidence risk by 0.15 (95% CI 1.08, 1.23, P < 0.001). PM2.5 exposure levels were significantly higher in Asian populations than in European populations; each incremental increase in PM2.5 exposure resulted in a rise in TSH by 0.27 mIU/L (95% CI 0.07, 0.47, P = 0.008) and a decrease in FT4 by 0.21 pmol/L (95% CI - .35, - 0.07, P = 0.004). Additionally, in susceptible pregnant women, each incremental increase in PM2.5 exposure during pregnancy was associated with a rise in TSH levels by 0.08 mIU/L (95% CI - 0.02, 0.17, P < 0.001) and a decrease in FT4 levels by 0.09 pmol/L (95% CI - 0.23, 0.05, P = 0.210).

Conclusion: Our research establishes PM2.5 exposure as a risk factor for diminished thyroid function. In Asian populations, the average level of PM2.5 exposure is high, significantly affecting thyroid hormones (TSH, FT4). Particular attention to PM2.5 exposure levels during pregnancy is essential to reduce the risk of thyroid dysfunction.

查看原文本刊更多论文

颗粒物质2.5与甲状腺功能和甲状腺癌之间的关系：一项荟萃分析。

目的：最近的研究表明，暴露于大气颗粒物2.5 （PM2.5）与甲状腺功能之间存在潜在联系，尽管流行病学结论仍不一致。这项综合系统综述和荟萃分析旨在阐明PM2.5水平与甲状腺功能和甲状腺癌风险之间的联系。方法：使用医学主题词“PM2.5”和“甲状腺激素”及其相关自由词，检索Web of Science、Embase、Cochrane Library和PubMed截至2024年4月的出版物。该研究方案已在PROSPERO注册（CRD42024554220）。结果：数据库共收集文献1322篇，其中27篇纳入分析。研究结果表明，PM2.5暴露是甲状腺功能减退的重要危险因素，使发病率增加0.15 （95% CI 1.08, 1.23， P）。结论：我们的研究确定PM2.5暴露是甲状腺功能减退的危险因素。在亚洲人群中，PM2.5暴露的平均水平很高，显著影响甲状腺激素（TSH, FT4）。在怀孕期间特别关注PM2.5暴露水平对于降低甲状腺功能障碍的风险至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.