Synovial D-dimer is a novel and accurate test for diagnosis of chronic knee periprosthetic joint infection.

IF 1.6 4区医学 Q3 ORTHOPEDICS

Knee Pub Date : 2025-03-19 DOI:10.1016/j.knee.2025.02.027

Zirvecan Güneş, Mehmet Kürşat Yılmaz, Bahattin Kemah, Ömür Çağlar, Ahmet Mazhar Tokgözoğlu, Javad Parvizi, İbrahim Azboy, Bülent Atilla

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引用次数: 0

Abstract

Background: Despite numerous tests and guidelines, diagnosing periprosthetic joint infection (PJI) remains challenging. The study aimed to determine the value of synovial D-dimer, rather than serum, in diagnosing PJI.

Methods: This prospective study enrolled 17 patients with chronic knee PJI (the PJI group) and 52 with primary knee osteoarthritis (the control group). PJI was defined using the 2018 International Consensus Meeting Criteria. Synovial D-dimer, plasma D-dimer, serum erythrocyte sedimentation rate, and serum C-reactive protein levels were measured. Synovial fluid D-dimer levels were determined using an enzyme-linked fluorescence assay. The performance of each biomarker in diagnosing PJI was evaluated using receiver operating characteristic (ROC) curves.

Results: The median synovial D-dimer level was significantly higher in the PJI group at (927,095 ng/ml, IQR 566,882-1,215,066) than in the control group (20,954 ng/ml, IQR 10,350-46,493) (P < 0.001). When the synovial D-dimer threshold value was determined to be 236,804 ng/ml, the sensitivity was 100% (CI 93.2-100%), and the specificity was 94.12% (95% CI 71.3-99.9). The area under the curve determined by ROC analysis was 0.992 (95% CI 0.992-1.000, P < 0.0001).

Conclusions: Patients with chronic knee PJI have significantly high synovial D-dimer levels, demonstrating that an increase in fibrinolytic activity coexists with an infection-induced inflammatory response. Synovial D-dimer levels appear to be valuable biomarkers for diagnosing PJI. However, further studies are required to evaluate the role of this novel biomarker.

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来源期刊

Knee 医学-外科

CiteScore

3.80

自引率

5.30%

发文量

171

审稿时长

6 months

期刊介绍： The Knee is an international journal publishing studies on the clinical treatment and fundamental biomechanical characteristics of this joint. The aim of the journal is to provide a vehicle relevant to surgeons, biomedical engineers, imaging specialists, materials scientists, rehabilitation personnel and all those with an interest in the knee. The topics covered include, but are not limited to: • Anatomy, physiology, morphology and biochemistry; • Biomechanical studies; • Advances in the development of prosthetic, orthotic and augmentation devices; • Imaging and diagnostic techniques; • Pathology; • Trauma; • Surgery; • Rehabilitation.