Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2025-03-15 DOI:10.1016/j.drup.2025.101239

Bram Van den Bergh , Philip Ruelens , Lieze Agten , Laurence Van Moll , Nele Geerts , Laure Verstraete , Sang Nguyen , Linda De Vooght , Natalie Verstraeten , Paul Cos , Jan Michiels

引用次数: 0

Abstract

Despite global efforts, antimicrobial resistance persists. Mechanisms like heterotolerance further undermine antibiotic effectiveness. Testing > 1000 clinical strains revealed widespread heterotolerance largely missed by conventional MIC-based diagnostics. Since AMR alone does not predict treatment success, new tests and strategies incorporating tolerance data are urgently needed to significantly improve patient outcomes.

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尽管全球都在努力，但抗生素耐药性依然存在。异耐药性等机制进一步削弱了抗生素的有效性。对超过 1000 株临床菌株进行测试后发现，基于 MIC 的传统诊断方法在很大程度上忽略了广泛的异耐药性。由于单凭 AMR 无法预测治疗的成功与否，因此迫切需要结合耐药性数据的新检测方法和策略，以显著改善患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research