Utilising Natural Language Processing to Identify Brain Tumour Patients for Clinical Trials: Development and Initial Evaluation.

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
James Booker, Jack Penn, Kawsar Noor, Richard J B Dobson, Naomi Fersht, Jonathan P Funnell, Ciaran S Hill, Danyal Z Khan, Nicola Newall, Tom Searle, Siddharth Sinha, Lewis Thorne, Simon C Williams, Michael Kosmin, Hani J Marcus
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引用次数: 0

Abstract

Background: Identifying patients eligible for clinical trials through eligibility screening is time and resource intensive. Natural Language Processing (NLP) models may enhance clinical trial screening by extracting data from Electronic Health Records (EHR).

Objective: We aimed to determine whether an NLP model can extract brain tumor diagnoses from outpatient clinic letters and link this with ongoing clinical trials.

Methods: This retrospective cohort study reviewed outpatient neuro-oncology clinic letters, to detect brain tumor diagnoses. We used an NLP model to perform named-entity-recognition + linking algorithm that identified medical concepts in free text and linked them to a Systematized Nomenclature of Medicine Clinical Terms (SNOMED-CT) ontology, which we used to search a clinical trials database. Human annotators reviewed the accuracy of the concepts extracted and the relevance of recommended clinical trials. Search results were shown on a notification dashboard accessible by clinicians and patients on the EHR. We report the model's performance using precision, recall and F1 scores.

Results: The model recognized 399 concepts across 196 letters with macro-precision=0.994, macro-recall=0.964 and macro-F1=0.977. Linking the model results with a clinical trials database identified 1,417 ongoing clinical trials, of these 755 were highly relevant to the individual patient, who met the eligibility criteria for trial recruitment.

Conclusions: NLP can be used effectively to extract brain tumor diagnoses from free-text EHR records with minimal additional training. The extracted concepts can then be linked to ongoing clinical trials. While further analysis is required to assess the impact on clinical outcomes, these findings suggest a potential application for integrating NLP algorithms into clinical care.

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来源期刊
World neurosurgery
World neurosurgery CLINICAL NEUROLOGY-SURGERY
CiteScore
3.90
自引率
15.00%
发文量
1765
审稿时长
47 days
期刊介绍: World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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