Distribution, biosynthesis, and synthetic biology of phenylethanoid glycosides in the order Lamiales.

IF 1.4 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Plant Biotechnology Pub Date : 2024-09-25 DOI:10.5511/plantbiotechnology.24.0720a

Yushiro Fuji, Hiroshi Matsufuji, Masami Yokota Hirai

引用次数: 0

Abstract

Phenylethanoid glycosides (PhGs), with a C₆-C₂ glucoside unit as the basic skeleton, are specialized (secondary) metabolites found in several medicinal plants. As PhGs exhibit various pharmacological activities, they are expected to be used as lead compounds in drug discovery. However, mass-production systems have not yet been established even for acteoside, a typical PhG that is widely distributed in nature (more than 150 species). This review focuses on recent studies on the accumulation and distribution of PhGs in plants, biosynthetic pathways of PhGs, and the bioproduction of PhGs.

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片叶目苯乙醇苷的分布、生物合成和合成生物学研究。

苯乙醇苷（Phenylethanoid glycosides, PhGs）是几种药用植物中发现的特化（次生）代谢物，以C6-C2糖苷单元为基本骨架。由于PhGs具有多种药理活性，有望成为药物开发的先导化合物。然而，即使是广泛分布于自然界（超过150种）的典型PhG——毛蕊花苷，也尚未建立大规模生产系统。本文综述了近年来植物中PhGs的积累和分布、PhGs的生物合成途径以及PhGs的生物生产等方面的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plant Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-PLANT SCIENCES

CiteScore

2.90

自引率

18.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Plant Biotechnology is an international, open-access, and online journal, published every three months by the Japanese Society for Plant Biotechnology. The journal, first published in 1984 as the predecessor journal, “Plant Tissue Culture Letters” and became its present form in 1997 when the society name was renamed to Japanese Society for Plant Cell and Molecular Biology, publishes findings in the areas from basic- to application research of plant biotechnology. The aim of Plant Biotechnology is to publish original and high-impact papers, in the most rapid turnaround time for reviewing, on the plant biotechnology including tissue culture, production of specialized metabolites, transgenic technology, and genome editing technology, and also on the related research fields including molecular biology, cell biology, genetics, plant breeding, plant physiology and biochemistry, metabolic engineering, synthetic biology, and bioinformatics.