Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells.

IF 3.7 3区生物学 Q1 DEVELOPMENTAL BIOLOGY

Reproduction Pub Date : 2025-04-01 Print Date: 2025-05-01 DOI:10.1530/REP-25-0042

Prianka H Hashim, Madeline J Perry, Michele T Pritchard, Jennifer L Gerton, Francesca E Duncan

引用次数: 0

Abstract

We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.

查看原文本刊更多论文

自主卵泡质量控制机制：颗粒细胞的先天免疫信号传导能力。

我们综合了目前的证据，证明颗粒细胞具有独特的先天性免疫信号传导能力。我们提出了一个新的概念，即颗粒细胞具有质量控制监控机制，它能整合来自卵母细胞和卵巢微环境的信号，防止质量差的卵泡产生配子，从而影响下一代。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Reproduction 生物-发育生物学

CiteScore

7.40

自引率

2.60%

发文量

199

审稿时长

4-8 weeks

期刊介绍： Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.