Developing plant-derived DNA repair enzyme resources through studying the involvement of base excision repair DNA glycosylases in stress responses of plants.

Abstract

DNA damage caused by internal and external stresses negatively affects plant growth and development. In this, DNA repair enzymes play an important role in recognizing and repairing the caused DNA damage. The first key enzymes in the base excision repair (BER) pathway are DNA glycosylases. In this paper, we present updated knowledge on the classification, phylogeny and conserved structural domains of DNA glycosylases in the plant base excision repair pathway. It describes the key roles played by the DNA glycosylases in plant stress responses, and focuses on the molecular mechanisms of plant stress tolerance from the perspective of the DNA repair system. New opportunities for the development of plant-derived DNA repair genes and DNA repair enzyme resources are discussed.