Case Finding Among and Comprehensive Management of Household Contacts of Persons with Pulmonary Tuberculosis: a Pilot Project - Uganda, 2023-2024.

IF 25.4 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

MMWR. Morbidity and mortality weekly report Pub Date : 2025-03-20 DOI:10.15585/mmwr.mm7409a1

Denis Mudoola, Pruthu Thekkur, Joseph Nsonga, Ritah Mande, Selma Dar Berger, Stavia Turyahabwe, Simon Muchuro, Proscovia Namuwenge, Moorine Sekadde, Deus Lukoye, Henry Luzze, John Paul Dongo, Anand Date, Riitta A Dlodlo, Odile Ferroussier-Davis, Macarthur Charles

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引用次数: 0

Abstract

To help achieve the End TB Strategy target of a 90% reduction in tuberculosis (TB) incidence by 2030, member states of the United Nations High-Level Meetings on TB called for improving provision of TB preventive treatment (TPT) for household contacts of persons with TB, who are at increased risk for infection and disease. However, TPT use among household contacts worldwide remained at 21% in 2023. The International Union Against Tuberculosis and Lung Disease, the Uganda Ministry of Health, and CDC piloted a comprehensive approach for increasing case finding and TPT coverage among household contacts of persons with TB. During November 1, 2023-September 30, 2024, a total of 521 index patients with TB disease were registered at six health facilities in Uganda. Home visits to index patients identified 1,913 household contacts, 1,739 (91.0%) of whom underwent TB symptom screening at home; 321 (18.5%) reported TB symptoms. Of 309 (96.3%) persons with TB symptoms who were further evaluated, 284 (91.9%) provided a sputum specimen for laboratory testing, including 270 (84.1% of those with symptoms) who did so during the home visit; 214 (69.3%) underwent chest radiography. Overall, 80 TB cases were diagnosed; in 61 (76.3%) persons, the diagnosis was based on radiographic findings. Among 1,496 HHCs eligible for TPT, 1,239 (82.8%) initiated treatment and 1,178 (95.1%) completed it. Global scale-up of this approach might help reach global TB elimination goals.

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肺结核家庭接触者的病例发现和综合管理：一个试点项目——乌干达，2023-2024年。

为帮助实现《终止结核病战略》关于到2030年将结核病发病率降低90%的具体目标，联合国结核病问题高级别会议成员国呼吁改善向感染和患病风险增加的结核病患者家庭接触者提供结核病预防治疗。然而，到2023年，全球家庭接触者的TPT使用率仍为21%。国际防治结核病和肺病联盟、乌干达卫生部和疾病预防控制中心试行了一种综合方法，以增加结核病患者家庭接触者的病例发现和破伤风三联疗法覆盖率。在2023年11月1日至2024年9月30日期间，乌干达六个卫生机构共登记了521名结核病指数患者。对指数患者的家访确定了1,913名家庭接触者，其中1,739人（91.0%）在家中接受了结核病症状筛查；321例（18.5%）报告有结核症状。在接受进一步评估的309名（96.3%）结核症状患者中，284名（91.9%）提供了痰标本供实验室检测，其中270名（84.1%）在家访期间提供了痰标本；214例（69.3%）行胸片检查。总共诊断出80例结核病例；61例（76.3%）患者的诊断是基于影像学表现。在1496例符合TPT条件的HHCs中，1239例（82.8%）开始治疗，1178例（95.1%）完成治疗。在全球推广这种方法可能有助于实现全球消除结核病的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

MMWR. Morbidity and mortality weekly report PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -

CiteScore

65.40

自引率

0.90%

发文量

309

期刊介绍： The Morbidity and Mortality Weekly Report (MMWR ) series is prepared by the Centers for Disease Control and Prevention (CDC). Often called “the voice of CDC,” the MMWR series is the agency’s primary vehicle for scientific publication of timely, reliable, authoritative, accurate, objective, and useful public health information and recommendations. MMWR readership predominantly consists of physicians, nurses, public health practitioners, epidemiologists and other scientists, researchers, educators, and laboratorians.