Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-03-20 DOI:10.1186/s12944-025-02531-8

Hongming Yin, Yongjin Wang, Yujia Chen, Qayyum Shehzad, Feng Xiao

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引用次数: 0

Abstract

Background: & aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists' attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.

Methods: The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.

Results: Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [OR_T3-T1 = 0.22 (0.12-0.41), OR_T3-T1 = 0.29 (0.15-0.54), OR_T3-T1 = 0.49 (0.27-0.88), and OR_T3-T1 = 0.19 (0.09-0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [OR_T1-T3 = 2.02 (1.11-3.70), OR_T1-T3 = 2.10 (1.15-3.87), OR_T1-T3 = 2.82 (1.53-5.30), and OR_T1-T3 = 2.07 (1.12-3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.

Conclusion: The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.

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红细胞脂肪酸组成与食管癌风险之间的关系：一项基于医院的病例对照研究。

背景与目的：食管癌（Esophageal cancer， EC）是一种侵袭性高、预后差的肿瘤类型，其发病机制和病因一直是科学家关注的焦点。鉴于关于EC风险与RBC脂肪酸之间的关联的证据有限且结果相互矛盾，我们旨在评估这种关联。方法：采用气相色谱法对158例EC患者和224例对照组的红细胞脂肪酸进行分析。采用多变量条件逻辑回归和限制三次样条分析来评估EC风险与RBC脂肪酸之间的关系，并确定这种关系的95%置信区间（OR, 95% CI）的比值比。结果：总n-3多不饱和脂肪酸（n-3 PUFA）、二十二碳六烯酸（DHA）、二十碳五烯酸（EPA）和n-3指数水平越高，发生EC的几率越低[ORT3-T1 = 0.22（0.12-0.41）、ORT3-T1 = 0.29（0.15-0.54）、ORT3-T1 = 0.49（0.27-0.88）和ORT3-T1 = 0.19(0.09-0.35)]。总饱和脂肪酸（SFA），特别是高浓度的棕榈酸（C16:0）、硬脂酸（C18:0）和花生四烯酸（C20:4n-6）与EC病例的高几率相关[ORT1-T3 = 2.02（1.11-3.70）、ORT1-T3 = 2.10（1.15-3.87）、ORT1-T3 = 2.82（1.53-5.30）和ORT1-T3 = 2.07(1.12-3.86)]。总单不饱和脂肪酸（MUFA）和总反式脂肪酸（TFA）与EC病例状态无显著相关性。结论：不同类型的红细胞脂肪酸对EC的易感性有显著影响。红细胞中总n-3 PUFA水平越高，特别是DHA和EPA，患EC的几率越低，而C20:4n-6、C18:0和C16:0水平越高，患EC的几率越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.