Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-03-20 DOI:10.1038/s41372-025-02266-5

Kazuki Nishizawa, Yoshinori Katayama, Yong-Kye Lee

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引用次数: 0

Abstract

Objective: To determine postnatal changes in total serum bilirubin (TB), unbound bilirubin (UB), and bilirubin-binding affinity of albumin (Ka) among Japanese newborns.

Study design: In a retrospective study, we evaluated for serum TB, UB, and albumin (Alb) levels, and their calculated UB/TB ratios, and Ka in 786 neonates born ≥36 weeks' gestation and analyzed to subcategories of three postnatal epochs: first, second, and ≥third weeks.

Result: TB levels were significantly higher (p < 0.01) at age ≥three weeks, while UB levels were significantly higher (p < 0.01) in the first week. UB/TB ratios were significantly lower while calculated Ka values were significantly higher as age-in-weeks increased (p < 0.01).

Conclusion: Hyperbilirubinemia in the first and second weeks of age in neonates born ≥36 weeks' gestation is associated with higher UB levels or UB/TB ratios with lower Ka and may potentially contribute to the risk of developing bilirubin neurotoxicity with aggravated variations in bilirubin, albumin and Ka.

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日本新生儿未结合胆红素和胆红素-白蛋白结合水平。

目的：探讨日本新生儿出生后血清总胆红素（TB）、未结合胆红素（UB）和白蛋白（Ka）的结合亲和力的变化。研究设计：在一项回顾性研究中，我们评估了786名妊娠≥36周的新生儿的血清TB、UB和白蛋白（Alb）水平，及其计算的UB/TB比率和Ka，并分析了三个产后时期的亚类别：第一周、第二周和≥第三周。结论：在妊娠≥36周出生的新生儿中，第1周和第2周的高胆红素血症与较高的UB水平或UB/TB比值与较低的Ka有关，并可能导致胆红素神经毒性的发生，同时胆红素、白蛋白和Ka的变化加剧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.