Consumption of Unsweetened Coffee or Tea May Reduce the Cancer Incidence and Mortality: A Prospective Cohort Study

IF 3.7 3区医学 Q2 NUTRITION & DIETETICS

Journal of Nutrition Pub Date : 2025-07-01 DOI:10.1016/j.tjnut.2025.03.016

Jingxue Xu , Yixue Wang , Siyu Wang , Tianle Zhou , Shijie Zhang , Zhengqian Li , Fuliang Liu , Hang Yin , Xiaoyuan Wang , Hongru Sun

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引用次数: 0

Abstract

Background

Current evidence on the relationship between beverage intake and cancer risk remains inconclusive.

Objectives

This study aimed to examine the association between the intake of 11 beverages and cancer incidence and mortality, with a particular focus on coffee and tea, categorized by their sugar content.

Methods

This large prospective cohort study included 189,020 participants from the United Kingdom Biobank. Multivariate Cox proportional hazard models were used to assess the association between beverage intake and the incidence and mortality of overall cancer and cancers of various systems. Additionally, the study investigated the effects of substituting 1 beverage for another and explored potential mediators underlying the relationship between beverage intake and cancer outcomes.

Results

Over a median follow-up period of 8.8 y, consuming >2 cups of unsweetened coffee per day was associated with reduced overall cancer incidence and mortality. Compared with no intake of unsweetened coffee, the hazard ratios (HRs) were 0.95 [95% confidence interval (CI): 0.92, 0.98] for overall cancer incidence and 0.89 (95% CI: 0.83, 0.96) for overall cancer mortality. Similarly, consuming >2 cups of unsweetened tea per day was associated with reduced overall cancer incidence (HR: 0.94, 95% CI: 0.92, 0.97) and mortality (HR: 0.84, 95% CI: 0.79, 0.91) compared with no unsweetened tea intake. Substituting unsweetened coffee or tea for other beverages was associated with a 1%–5% reduction in overall cancer incidence and mortality. The association between unsweetened tea and reduced cancer risk may be partially mediated by inflammatory markers. Notably, the sugar content of coffee and tea had the most pronounced effect on risk of respiratory system cancers.

Conclusions

Beverage selection significantly impacts cancer incidence and mortality. For cancer prevention, unsweetened tea or coffee may be the optimal choice.

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饮用不加糖的咖啡或茶可降低癌症发病率和死亡率：一项前瞻性队列研究

背景：目前关于饮料摄入量与癌症风险之间关系的证据仍不确定。目的：本研究旨在研究11种饮料的摄入量与癌症发病率和死亡率之间的关系，特别关注咖啡和茶，根据其含糖量进行分类。方法：这项大型前瞻性队列研究包括来自英国生物银行的189020名参与者。使用多变量Cox比例风险模型来评估饮料摄入量与总体癌症和各种系统癌症的发病率和死亡率之间的关系。此外，该研究还调查了用一种饮料替代另一种饮料的影响，并探索了饮料摄入量与癌症结果之间关系的潜在中介。结果：在中位8.8年的随访期内，每天饮用两杯以上的无糖咖啡与降低总体癌症发病率和死亡率有关。与不摄入无糖咖啡相比，总体癌症发病率的风险比（hr）为0.95(95%可信区间[CI]: 0.92-0.98)，总体癌症死亡率的风险比（hr）为0.89（95%可信区间[CI]: 0.83-0.96）。同样，与不喝无糖茶相比，每天喝两杯以上的无糖茶与降低总体癌症发病率（HR: 0.94, 95% CI: 0.92-0.97）和死亡率（HR: 0.84, 95% CI: 0.79-0.91）有关。用不加糖的咖啡或茶代替其他饮料，总体癌症发病率和死亡率降低了1%至5%。无糖茶与降低癌症风险之间的联系可能部分是由炎症标志物介导的。值得注意的是，咖啡和茶的含糖量对患呼吸系统癌症的风险有最明显的影响。结论：饮料选择对癌症发病率和死亡率有显著影响。为了预防癌症，不加糖的茶或咖啡可能是最佳选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition 医学-营养学

CiteScore

7.60

自引率

4.80%

发文量

260

审稿时长

39 days

期刊介绍： The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.