Pharmacokinetics and Bioavailability of Single-Dose Intramuscular and Intravenous Administration of Thiafentanil in Goats (Capra hircus).

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Judith T Christie, Mieghan Bruce, Silke Pfitzer, Liesel Laubscher, Jacobus P Raath, Michael Laurence, Tracy Kellermann, Andrew P Woodward
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引用次数: 0

Abstract

Thiafentanil is a popular opioid agonist used for wildlife chemical immobilisation. Its effects are quickly and completely reversed by the antagonist naltrexone. Successful wildlife immobilisations using thiafentanil have been documented in a variety of wildlife species globally. The aim of this study was to describe the single-dose intramuscular (IM) and intravenous (IV) pharmacokinetics of thiafentanil in goats at a dose of 90 μg/kg using a single cross-over study. The IM dose was administered in the left Vastus lateralis. Plasma samples were collected up to 120 min after thiafentanil administration from two female and eight male adult goats. Samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters from one and two-compartment models were estimated via a Bayesian approach. The two-compartment model was preferred overall. The estimated bioavailability was 0.677 (90% Crl: 0.542-0.888), absorption rate constant (ka) was 0.058 1/min (90% Crl: 0.045-0.115) and clearance was 29.0 mL/min/kg (90% Crl: 23.7-36.3) from this model. This study provides key pharmacokinetic data on thiafentanil, supporting a two-compartment model and offering insights into its absorption, bioavailability, and clearance when used for wildlife immobilisation.

山羊(Capra hircus)单剂量肌肉注射和静脉注射噻芬太尼的药代动力学和生物利用度。
噻芬太尼是一种常用的阿片类激动剂,用于野生动物的化学固定。它的作用被拮抗剂纳曲酮迅速而完全地逆转。使用噻芬太尼成功固定野生动物已被记录在全球各种野生动物物种中。本研究的目的是通过单次交叉研究,描述90 μg/kg剂量的噻芬太尼在山羊体内的肌肉注射(IM)和静脉注射(IV)药物动力学。IM给药于左股外侧肌。在给药后120分钟内采集2只母山羊和8只公山羊的血浆样本。采用液相色谱-串联质谱(LC-MS/MS)对样品进行分析。通过贝叶斯方法估计单室和双室模型的药代动力学参数。总的来说,双室模型是首选的。该模型估计生物利用度为0.677 (90% Crl: 0.542-0.888),吸收速率常数(ka)为0.058 1/min (90% Crl: 0.045-0.115),清除率为29.0 mL/min/kg (90% Crl: 23.7-36.3)。该研究提供了关于噻芬太尼的关键药代动力学数据,支持双室模型,并提供了其用于野生动物固定时的吸收、生物利用度和清除的见解。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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