Prevalence and concomitance of diabetic peripheral sensory neuropathy and lower limb peripheral arterial disease in type II diabetics and its correlation with obesity.

IF 1.1 Q4 PRIMARY HEALTH CARE
Jayesh Dalpatbhai Solanki, Axat Pragnesh Shah, Nisha Lalwani, Bansi Janakbhai Trivedi, Avan Ashokbhai Savani, Krupali Parshottambhai Sojitra
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引用次数: 0

Abstract

Introduction: Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their association with obesity. Qualitative and general body fat parameters give a complete picture of obesity. We studied the association of vibration perception threshold (VPT)-based DSPN and ankle brachial pressure index (ABPI))-based PAD, and the effect of obesity on them, in T2Ds.

Methods: A cross-sectional study was done on 152 under-treatment T2Ds. Bio-esthesiometer-based VPT from the sole of each foot and VersaDop-based ABPI from all limbs were assessed. Prevalence of DSPN (VPT ≥25) and PAD (ABPI ≤0.9) was measured and compared for concomitance. The odds ratio was used for testing association and multiple linear regressions were accomplished for predictors of VPT and ABPI taking P value < 0.05 as statistically significant.

Results: T2Ds had a mean age of 53 years, a mean duration of 67 months, and 48% glycemic control. The prevalence of abnormal VPT and ABPI was 64% and 23%, respectively. VPT-based subgroups do not defer significantly from ABPI and vice versa. Obesity was associated with only abnormal ABPI (visceral > general). Odd's ratio for neuropathy with vasculopathy was insignificant while VPT and ABPI had differences in significant predictors.

Conclusion: T2Ds having 64% neuropathy and 23% vasculopathy had one-third concomitance but lack of association and different predictors for each. Vasculopathy not neuropathy was associated with obesity; visceral more than general; suggesting scope for its rectification. It suggests different progression of these complications, despite some cross-talk between them.

糖尿病周围感觉神经病变和下肢外周动脉病变在II型糖尿病患者中的患病率、伴发性及其与肥胖的相关性
在2型糖尿病(T2D)患者中,大血管并发症下肢外周动脉病变(PAD)和微血管并发症糖尿病外周感觉神经病变(DPSN)的一致性及其与肥胖的相关性研究很少。定性的和一般性的身体脂肪参数给出了肥胖的全貌。我们研究了t2d患者基于振动感知阈值(VPT)的DSPN和基于踝肱压力指数(ABPI)的PAD的相关性,以及肥胖对它们的影响。方法:对152例治疗不足的t2dm患者进行横断面研究。评估每只脚底基于生物感觉仪的VPT和四肢基于versadopi的ABPI。测量DSPN (VPT≥25)和PAD (ABPI≤0.9)的患病率并比较其伴发性。采用比值比检验相关性,以P值< 0.05为差异有统计学意义,对预测因子VPT和ABPI进行多元线性回归。结果:T2Ds患者平均年龄53岁,平均病程67个月,血糖控制48%。VPT和ABPI异常发生率分别为64%和23%。基于vpt的亚组对ABPI没有明显的延迟,反之亦然。肥胖仅与异常的ABPI(内脏>一般)相关。神经病变合并血管病变的Odd比值不显著,而VPT和ABPI在预测指标上有显著差异。结论:有64%的神经病变和23%的血管病变的t2dm有三分之一的伴发性,但两者缺乏相关性和不同的预测指标。血管病变而非神经病变与肥胖有关;内脏多于一般;建议整改范围。这表明这些并发症的进展不同,尽管它们之间存在一些交叉。
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7.10%
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审稿时长
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