Spectrum of cancer risk in Asian American and Pacific Islander solid organ transplant recipients.

IF 9.9 1区医学 Q1 ONCOLOGY

JNCI Journal of the National Cancer Institute Pub Date : 2025-03-18 DOI:10.1093/jnci/djaf069

Jun Tao, Jaimie Z Shing, Kelly Yu, Aimée R Kreimer, Mei-Chin Hsieh, Karen S Pawlish, Jie Li, Baozhen Qiao, Judy R Rees, Kekoa Taparra, Jacqueline B Vo, Eric A Engels

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引用次数: 0

Abstract

Background: Solid organ transplant recipients (SOTRs) have increased cancer risk, which may differ across racial groups. Cancer risk among Asian American and Pacific Islander SOTRs is ill-defined.

Methods: We evaluated Asian, Pacific Islander, and White SOTRs from a linkage of the United States SOTR registry with 34 cancer registries (1990-2019). We calculated age-and-sex adjusted incidence rate ratios (aIRRs) to compare cancer risk between races and standardized incidence ratios (SIRs) to measure risk relative to race-matched general populations.

Results: Compared with Asian SOTRs, Pacific Islander SOTRs had notably higher incidence of pancreatic cancer (aIRR = 3.7, 95%CI = 1.6-8.6) and melanoma (aIRR = 6.7, 95%CI = 1.2-36). Compared with White SOTRs, Asian and Pacific Islander SOTRs had lower melanoma incidence but higher nasopharyngeal carcinoma incidence. Compared with the general population, Asian SOTRs had increased risk of cancers of the anus (SIR = 7.9, 95%CI = 3.6-15), penis (SIR = 8.9, 95%CI = 2.9-21), non-epithelial skin (SIR = 9.8, 95%CI = 5.4-17), kidney (SIR = 5.3, 95%CI = 4.3-6.5), and renal pelvis (SIR = 7.4, 95%CI = 3.7-13); non-Hodgkin lymphoma including chronic lymphocytic leukemia (NHL/CLL) (SIR = 6.4, 95%CI = 5.6-7.3); Hodgkin lymphoma (SIR = 6.1, 95%CI = 2.8-12); and Kaposi sarcoma (SIR = 15, 95%CI = 6.6-30). Compared with the general population, Pacific Islander SOTRs had increased risk of cancers of the anus (SIR:12, 95%CI = 1.5-45), pancreas (SIR = 3.3, 95%CI = 1.3-6.8), non-epithelial skin (SIR = 9.3, 95%CI = 1.1, 34), and thyroid (SIR = 3.4, 95%CI = 1.2-7.4); NHL/CLL (SIR = 4.5, 95%CI = 2.3-7.9); and Kaposi sarcoma (SIR = 71, 95%CI = 8.6-258).

Conclusions: Asian, Pacific Islander and White SOTRs all experienced elevated cancer risk compared with their race-matched general population. Different cancer risks in these racial groups might be explained by differences in risk factors in the general population or unique features of SOTRs in these groups.

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亚裔美国人和太平洋岛民实体器官移植受者的癌症风险谱。

背景：实体器官移植接受者（SOTRs）患癌症的风险增加，这可能在种族群体中有所不同。亚裔美国人和太平洋岛民SOTRs的癌症风险尚不明确。方法：我们从美国SOTR登记处与34个癌症登记处（1990-2019）的链接中评估了亚洲、太平洋岛民和白人SOTR。我们计算了年龄和性别调整后的发病率比（airr）来比较种族之间的癌症风险，并计算了标准化发病率比（SIRs）来衡量相对于种族匹配的一般人群的风险。结果：与亚洲SOTRs相比，太平洋岛族SOTRs胰腺癌（aIRR = 3.7, 95%CI = 1.6 ~ 8.6）和黑色素瘤（aIRR = 6.7, 95%CI = 1.2 ~ 36）的发病率明显高于亚洲岛族SOTRs。与白人SOTRs相比，亚洲和太平洋岛民SOTRs黑色素瘤发病率较低，鼻咽癌发病率较高。与一般人群相比，亚洲SOTRs患肛门癌（SIR = 7.9, 95%CI = 3.6-15）、阴茎癌（SIR = 8.9, 95%CI = 2.9-21）、非上皮性皮肤癌（SIR = 9.8, 95%CI = 5.4-17）、肾脏癌（SIR = 5.3, 95%CI = 4.3-6.5）和肾盂癌（SIR = 7.4, 95%CI = 3.7-13）的风险增加；非霍奇金淋巴瘤包括慢性淋巴细胞白血病（NHL/CLL）（SIR = 6.4, 95%CI = 5.6-7.3）；霍奇金淋巴瘤（SIR = 6.1, 95%CI = 2.8-12）；卡波西肉瘤（SIR = 15, 95%CI = 6.6-30）。与一般人群相比，太平洋岛民SOTRs患肛门癌（SIR = 12, 95%CI = 1.5-45）、胰腺癌（SIR = 3.3, 95%CI = 1.3-6.8）、非上皮性皮肤癌（SIR = 9.3, 95%CI = 1.1, 34）和甲状腺癌（SIR = 3.4, 95%CI = 1.2-7.4）的风险增加；Nhl / cll (sir = 4.5, 95%ci = 2.3-7.9)；Kaposi肉瘤（SIR = 71, 95%CI = 8.6-258）。结论：与种族匹配的一般人群相比，亚洲人、太平洋岛民和白人sotr患癌症的风险都较高。这些种族群体中不同的癌症风险可能是由一般人群中风险因素的差异或这些群体中sotr的独特特征来解释的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JNCI Journal of the National Cancer Institute 医学-肿瘤学

CiteScore

17.00

自引率

2.90%

发文量

203

审稿时长

4-8 weeks

期刊介绍： The Journal of the National Cancer Institute is a reputable publication that undergoes a peer-review process. It is available in both print (ISSN: 0027-8874) and online (ISSN: 1460-2105) formats, with 12 issues released annually. The journal's primary aim is to disseminate innovative and important discoveries in the field of cancer research, with specific emphasis on clinical, epidemiologic, behavioral, and health outcomes studies. Authors are encouraged to submit reviews, minireviews, and commentaries. The journal ensures that submitted manuscripts undergo a rigorous and expedited review to publish scientifically and medically significant findings in a timely manner.