Anne Wang, Athena Adeli, David Kylhammar, Eva Swahn, Jan E Engvall, Lars Lind, Stefan Söderberg, Anders Blomberg, Gunnar Engström, Jonas Spaak, Henrik Löfmark, Carl Johan Östgren, Tomas Jernberg, Göran Bergström, Magnus Settergren, Bahira Shahim
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引用次数: 0
Abstract
Aim: Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis which is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population.
Methods: Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30,154 individuals 50 to 64 years from the general population recruited in Sweden between 2013-2018. AVC was assessed visually on computed tomography (CT) and categorized as evident or not. Population attributable risk proportion (PARP) was calculated for six modifiable risk factors (smoking, hypertension, hyperlipidemia, diabetes, BMI ≥median and kidney dysfunction [eGFR <60 ml/min/1.73 m2]).
Results: In total, 29,221 individuals with CT images available were included (mean age 57.5 years, 51% female) and AVC was present in 2,053 (7%). The AVC prevalence increased with age (50-54 years: 3%; 55-59 years: 7%; 60-64 years: 11%). In analyses adjusted for age, sex, smoking and study site, male sex (OR 2.02, 95% CI 1.84-2.22), hyperlipidemia (1.88 [1.68-2.11]), hypertension (1.73 [1.57-1.91]), diabetes (1.66 [1.39-1.97]), kidney dysfunction (1.54 [1.10-2.11]), smoking (1.36 [1.24-1.50]), age (increment by one year) (1.12 [1.11-1.13]) and BMI (increment by one unit) (1.04 [1.03-1.05) were associated with AVC. The PARP of AVC associated with the six modifiable risk factors was 34.5% (95% CI 29.6-39.4).
Conclusions: In this large, contemporary middle-aged general population, AVC was prevalent in as many as 7% and six cardiovascular risk factors contributed to one third of the prevalence of AVC.
期刊介绍：
European Journal of Preventive Cardiology (EJPC) is an official journal of the European Society of Cardiology (ESC) and the European Association of Preventive Cardiology (EAPC). The journal covers a wide range of scientific, clinical, and public health disciplines related to cardiovascular disease prevention, risk factor management, cardiovascular rehabilitation, population science and public health, and exercise physiology. The categories covered by the journal include classical risk factors and treatment, lifestyle risk factors, non-modifiable cardiovascular risk factors, cardiovascular conditions, concomitant pathological conditions, sport cardiology, diagnostic tests, care settings, epidemiology, pharmacology and pharmacotherapy, machine learning, and artificial intelligence.
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