Napkin-ring sign plaques are associated with cerebral small vessel disease.

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-03-21 DOI:10.1186/s40001-025-02371-3

Hui Zhou, Qiao Lin, Xinwei He, Rui Huang, Linkao Chen

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引用次数: 0

Abstract

Background: Few studies have investigated the association between the carotid artery napkin-ring sign (NRS) and cerebral small vessel disease (CSVD). This study aimed to investigate whether carotid NRS plaque burden and CSVD are associated.

Methods: This retrospective, single-center, cross-sectional study following STROBE guidelines enrolled patients with symptoms or clinical suspicion of anterior circulation acute ischemic stroke (AIS). Plaques were evaluated using preoperative cervicocerebral computed tomography angiography (CTA). Imaging markers of CSVD, such as white matter hyperintensities (WMHs) and perivascular spaces (PVSs), were assessed.

Results: A total of 575 patients (64.9 ± 8.0 years, 378 men) were evaluated. Patients with AIS had a higher percentage of total NRS plaques than those in the control group (144 (37.1%) vs. 45 (24.1%), P = 0.002), and the total NRS amount increased the risk of AIS after adjusting for confounding factors (odds ratio 1.717; 95%CI 1.141-2.584; P = 0.009). A higher WMHs grade was associated with the presence of NRS plaques (P < 0.001) and a higher total NRS area (P < 0.001). A higher PVSs grade was associated with positive remodeling (PR) on the NRS (P = 0.006).

Conclusions: An increased incidence of NRS plaques on CTA was associated with the occurrence of AIS, and the area and PR of NRS plaques were associated with the risk stratification of CSVD.

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餐巾环征斑块与脑血管疾病有关。

背景：很少有研究调查颈动脉餐巾环征（NRS）与脑小血管疾病（CSVD）之间的关联。本研究旨在探讨颈动脉 NRS 斑块负荷与 CSVD 是否相关：这项遵循 STROBE 指南的回顾性、单中心、横断面研究招募了有前循环急性缺血性卒中（AIS）症状或临床怀疑的患者。术前使用颈脑计算机断层扫描血管造影术（CTA）对斑块进行评估。对白质高密度（WMH）和血管周围间隙（PVS）等 CSVD 的影像标记进行了评估：共评估了 575 名患者（64.9 ± 8.0 岁，378 名男性）。与对照组相比，AIS 患者的总 NRS 斑块比例更高（144 (37.1%) vs. 45 (24.1%)，P = 0.002），调整混杂因素后，总 NRS 数量会增加 AIS 风险（几率比 1.717；95%CI 1.141-2.584；P = 0.009）。WMHs等级越高，出现NRS斑块的风险越高（P=0.009）：CTA上NRS斑块发生率的增加与AIS的发生有关，NRS斑块的面积和PR与CSVD的风险分层有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.