Association of sarcopenia index, a surrogate marker of muscle mass, and incident chronic kidney disease

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-03-18 DOI:10.1016/j.clnesp.2025.03.019

Fan Zhang , Aojiao Chu , Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li

{"title":"Association of sarcopenia index, a surrogate marker of muscle mass, and incident chronic kidney disease","authors":"Fan Zhang , Aojiao Chu , Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li","doi":"10.1016/j.clnesp.2025.03.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia, characterized by loss of muscle mass and strength, has been linked to various health outcomes, including chronic kidney disease (CKD). This study aims to investigate the association of sarcopenia index, based on serum creatinine and cystatin C levels, with incident CKD in middle-aged and older adults.</div></div><div><h3>Methods</h3><div>This study extracted data from a nation cohort, including age ≥45 years adults without CKD at baseline. Sarcopenia index was calculated based on serum creatinine and cystatin C levels, and incident CKD was assessed through follow-up surveys. Cox proportional hazards regression models were used to analyze the association between sarcopenia index and incident CKD, adjusting for potential confounders, with hazard ratio (HR) with 95 % confidence interval (95 % CI) reported.</div></div><div><h3>Results</h3><div>A total of 8618 participants were included in the analysis. The median age was 61.0 years, and 44.7 % were male. During a mean follow-up period of 5.0 years, 514 cases of incident CKD were identified. After adjusting for covariates, compared with participants in the lowest tertile, the corresponding CKD HRs (95 % CIs) for participants in the medium and highest tertile were 0.701 (95 % CI: 0.558–0.880, <em>P</em> = 0.002), 0.784 (95 % CI: 0.618–0.994; <em>P</em> = 0.045). Restricted cubic spline curves revealed that incident rate decreased with increase in sarcopenia index.</div></div><div><h3>Conclusion</h3><div>This study provides national longitudinal evidence on the association of higher sarcopenia index with lower incident CKD. Our findings suggest that sarcopenia index may be a useful biomarker for predicting the risk of CKD in this population.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"67 ","pages":"Pages 184-191"},"PeriodicalIF":2.9000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S240545772500110X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Sarcopenia, characterized by loss of muscle mass and strength, has been linked to various health outcomes, including chronic kidney disease (CKD). This study aims to investigate the association of sarcopenia index, based on serum creatinine and cystatin C levels, with incident CKD in middle-aged and older adults.

Methods

This study extracted data from a nation cohort, including age ≥45 years adults without CKD at baseline. Sarcopenia index was calculated based on serum creatinine and cystatin C levels, and incident CKD was assessed through follow-up surveys. Cox proportional hazards regression models were used to analyze the association between sarcopenia index and incident CKD, adjusting for potential confounders, with hazard ratio (HR) with 95 % confidence interval (95 % CI) reported.

Results

A total of 8618 participants were included in the analysis. The median age was 61.0 years, and 44.7 % were male. During a mean follow-up period of 5.0 years, 514 cases of incident CKD were identified. After adjusting for covariates, compared with participants in the lowest tertile, the corresponding CKD HRs (95 % CIs) for participants in the medium and highest tertile were 0.701 (95 % CI: 0.558–0.880, P = 0.002), 0.784 (95 % CI: 0.618–0.994; P = 0.045). Restricted cubic spline curves revealed that incident rate decreased with increase in sarcopenia index.

Conclusion

This study provides national longitudinal evidence on the association of higher sarcopenia index with lower incident CKD. Our findings suggest that sarcopenia index may be a useful biomarker for predicting the risk of CKD in this population.

查看原文本刊更多论文

肌肉质量的代用指标--肌肉疏松指数与慢性肾脏病发病率的关系。

背景：肌肉减少症以肌肉质量和力量的减少为特征，与多种健康结果有关，包括慢性肾脏疾病（CKD）。本研究旨在探讨基于血清肌酐和胱抑素C水平的肌肉减少症指数与中老年CKD发病率的关系。方法：本研究从一个国家队列中提取数据，包括基线时年龄≥45岁无CKD的成年人。根据血清肌酐和胱抑素C水平计算肌少症指数，并通过随访调查评估CKD的发生率。使用Cox比例风险回归模型分析肌肉减少症指数与CKD事件之间的关系，调整潜在混杂因素，报告95%置信区间（95% CI）的风险比（HR）。结果：共有8618名参与者被纳入分析。中位年龄为61.0岁，44.7%为男性。在平均5.0年的随访期间，确定了514例CKD事件。调整协变量后，与最低分位数的受试者相比，中等和最高分位数受试者相应的CKD hr （95% CI）分别为0.701 （95% CI: 0.558-0.880， P=0.002）、0.784 (95% CI: 0.618-0.994；P = 0.045)。限制三次样条曲线显示，发病率随肌少症指数的增加而降低。结论：本研究为高肌肉减少指数与低CKD发生率之间的关系提供了全国性的纵向证据。我们的研究结果表明，肌少症指数可能是预测该人群CKD风险的有用生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.