Evidence for Transgenerational Immunity in Antiviral Immunity in Silkworm, Bombyx mori

IF 1.5 4区农林科学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Archives of Insect Biochemistry and Physiology Pub Date : 2025-03-21 DOI:10.1002/arch.70041

Qiang Wang, Zengqing Huang, FeiFei Wang, Zhonghe Sun, Xiaoli Ju, Keping Chen

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Abstract

Transgenerational immune priming (TGIP) is a phenomenon in which parental exposure to pathogen infection enhances resistance to pathogens in their offspring. TGIP has been reported in several insects, including Lepidoptera, but it has not yet been documented in silkworms. In this study, we demonstrated the existence of TGIP in silkworms by exposing the parental generation to a low dose of Bombyx mori nucleopolyhedrovirus (BmNPV). Notably, when maternal or paternal-primed moths were mated to produce the F1 generation, the F1 generation larvae from both primed groups were more resistant to the BmNPV challenge than silkworm larvae with only maternal or paternal priming. Importantly, both maternal and paternal contributions to offspring immunity were essential for TGIP. However, due to the characteristics of the BmNPV itself, no within-generation immune responses were detected following BmNPV priming. Further analysis revealed that immune-related genes might play a role in mediating specific TGIP in silkworms after BmNPV priming. These results broaden our understanding of TGIP and the antiviral memory of insects in their offspring.

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桑蚕抗病毒免疫中跨代免疫的证据

跨代免疫启动（TGIP）是一种现象，在这种现象中，父母接触病原体感染可以增强其后代对病原体的抵抗力。据报道，包括鳞翅目在内的几种昆虫中都有TGIP，但在家蚕中尚未见记录。在这项研究中，我们通过将家蚕亲代暴露于低剂量的家蚕核多角病毒（BmNPV），证明了TGIP在家蚕体内的存在。值得注意的是，当母本或父本启动产生F1代时，两个启动组的F1代幼虫对BmNPV的抗性都比只母本或父本启动的家蚕幼虫强。重要的是，母亲和父亲对后代免疫的贡献对TGIP至关重要。然而，由于BmNPV本身的特点，在BmNPV启动后未检测到代内免疫反应。进一步分析表明，免疫相关基因可能在家蚕BmNPV启动后介导特异性TGIP中发挥作用。这些结果拓宽了我们对TGIP和昆虫后代抗病毒记忆的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Insect Biochemistry and Physiology 生物-昆虫学

CiteScore

4.30

自引率

4.50%

发文量

115

审稿时长

12 months

期刊介绍： Archives of Insect Biochemistry and Physiology is an international journal that publishes articles in English that are of interest to insect biochemists and physiologists. Generally these articles will be in, or related to, one of the following subject areas: Behavior, Bioinformatics, Carbohydrates, Cell Line Development, Cell Signalling, Development, Drug Discovery, Endocrinology, Enzymes, Lipids, Molecular Biology, Neurobiology, Nucleic Acids, Nutrition, Peptides, Pharmacology, Pollinators, Proteins, Toxicology. Archives will publish only original articles. Articles that are confirmatory in nature or deal with analytical methods previously described will not be accepted.