{"title":"Efficacy of statins in tissue healing following tooth extraction: a systematic review of animal studies.","authors":"Karthik Kommuri, Mayank Kakkar, Neha Mehta, Maryam Altuhafy, Pooja Gangwani, Junad Khan","doi":"10.21037/atm-24-140","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Statins, with their unique ability to stimulate bone formation and soft tissue healing, hold the potential to revolutionize dental care. The present study aims to delve into the profound effects of statins on bone and soft tissue healing in dental extraction sockets, offering a promising future for dental professionals and patients alike.</p><p><strong>Methods: </strong>This systematic review aimed to understand the role of stains in tissue healing following dental extraction. This study was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO; CRD42022299247). A comprehensive electronic database search yielded 412 manuscripts. After a rigorous screening process, nine manuscripts met the eligibility criteria. The study sample consisted of 403 animals, with eight studies utilizing rat animal models and one conducted on mongrel dogs.</p><p><strong>Results: </strong>Overall, the application of statin drugs holds promise for improving tissue healing outcomes following tooth extraction. The primary outcome variables across all studies were residual ridge height and width, messenger ribonucleic acid (mRNA) expression of transforming growth factor-beta 1 (TGF-β1), bone morphogenetic protein-2 (BMP-2), and vascular endothelial growth factor (VEGF), bone and gingival healing, inflammatory response, and bone turnover (BT), bone formation in tooth extraction socket, and osteogenic healing in a tooth extraction socket.</p><p><strong>Conclusions: </strong>The findings of this study underscore the significant potential of statin drugs to enhance tissue healing outcomes following tooth extraction. This discovery opens new and exciting possibilities for improving dentistry patient care, potentially transforming how we approach post-extraction healing.</p>","PeriodicalId":8216,"journal":{"name":"Annals of translational medicine","volume":"13 1","pages":"5"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921178/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of translational medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/atm-24-140","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background: Statins, with their unique ability to stimulate bone formation and soft tissue healing, hold the potential to revolutionize dental care. The present study aims to delve into the profound effects of statins on bone and soft tissue healing in dental extraction sockets, offering a promising future for dental professionals and patients alike.
Methods: This systematic review aimed to understand the role of stains in tissue healing following dental extraction. This study was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO; CRD42022299247). A comprehensive electronic database search yielded 412 manuscripts. After a rigorous screening process, nine manuscripts met the eligibility criteria. The study sample consisted of 403 animals, with eight studies utilizing rat animal models and one conducted on mongrel dogs.
Results: Overall, the application of statin drugs holds promise for improving tissue healing outcomes following tooth extraction. The primary outcome variables across all studies were residual ridge height and width, messenger ribonucleic acid (mRNA) expression of transforming growth factor-beta 1 (TGF-β1), bone morphogenetic protein-2 (BMP-2), and vascular endothelial growth factor (VEGF), bone and gingival healing, inflammatory response, and bone turnover (BT), bone formation in tooth extraction socket, and osteogenic healing in a tooth extraction socket.
Conclusions: The findings of this study underscore the significant potential of statin drugs to enhance tissue healing outcomes following tooth extraction. This discovery opens new and exciting possibilities for improving dentistry patient care, potentially transforming how we approach post-extraction healing.
期刊介绍：
The Annals of Translational Medicine (Ann Transl Med; ATM; Print ISSN 2305-5839; Online ISSN 2305-5847) is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research, aiming to provide practical up-to-date information in significant research from all subspecialties of medicine and to broaden the readers’ vision and horizon from bench to bed and bed to bench. It is published quarterly (April 2013- Dec. 2013), monthly (Jan. 2014 - Feb. 2015), biweekly (March 2015-) and openly distributed worldwide. Annals of Translational Medicine is indexed in PubMed in Sept 2014 and in SCIE in 2018. Specific areas of interest include, but not limited to, multimodality therapy, epidemiology, biomarkers, imaging, biology, pathology, and technical advances related to medicine. Submissions describing preclinical research with potential for application to human disease, and studies describing research obtained from preliminary human experimentation with potential to further the understanding of biological mechanism underlying disease are encouraged. Also warmly welcome are studies describing public health research pertinent to clinic, disease diagnosis and prevention, or healthcare policy. With a focus on interdisciplinary academic cooperation, ATM aims to expedite the translation of scientific discovery into new or improved standards of management and health outcomes practice.
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