Basal ganglia connectivity and network asymmetry in Parkinson’s disease: A resting-state fMRI study

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-18 DOI:10.1016/j.brainres.2025.149576

Yan Liu , Yu Cheng , Tianran Chen , Jun Wang , Jiajin He , Fuwu Yan , Lirong Yan

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引用次数: 0

Abstract

This study investigates the impact of basal ganglia network asymmetry on motor function in Parkinson’s Disease (PD). Using resting-state functional magnetic resonance imaging (rs-fMRI), functional connectivity and network asymmetry were analyzed in 15 non-demented PD patients and 15 healthy controls. Sixteen basal ganglia substructures, including the caudate, putamen, and globus pallidus, were selected for a unified analysis of variance framework to evaluate inter-hemispheric connectivity differences.

After spatial preprocessing, regions of interest were defined, and time-series data were extracted for functional connectivity and network asymmetry analysis. The results revealed significant alterations in the functional connectivity of the caudate, putamen, and nucleus accumbens (NAc) in PD patients. Notably, the absence of intra-network asymmetry in the left NAc and bilateral amygdala correlated with motor dysfunction, likely due to overactivity of the inhibitory indirect pathway. Furthermore, pronounced asymmetry in the left putamen and right frontal gyrus suggested a compensatory neural mechanism supporting motor performance.

These findings highlight the critical role of basal ganglia network asymmetry in the pathophysiology of PD. The identified asymmetry characteristics may serve as potential biomarkers for early diagnosis and disease progression monitoring, offering new directions for targeted therapeutic interventions.

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帕金森病的基底神经节连通性和网络不对称性：静息态 fMRI 研究。

本研究探讨基底神经节网络不对称对帕金森病（PD）运动功能的影响。应用静息状态功能磁共振成像（rs-fMRI）分析了15例PD非痴呆患者和15例健康对照者的功能连通性和网络不对称性。16个基底神经节亚结构，包括尾状核、壳核和苍白球，被选择用于统一的方差框架分析，以评估半球间连通性差异。空间预处理后，定义感兴趣区域，提取时间序列数据进行功能连通性和网络不对称性分析。结果显示，PD患者的尾状核、壳核和伏隔核（NAc）的功能连通性发生了显著变化。值得注意的是，左侧NAc和双侧杏仁核中网络内不对称的缺失与运动功能障碍相关，可能是由于抑制间接通路的过度活跃。此外，左侧壳核和右侧额回的明显不对称提示了支持运动表现的代偿神经机制。这些发现强调了基底神经节网络不对称在PD病理生理中的关键作用。发现的不对称特征可能作为早期诊断和疾病进展监测的潜在生物标志物，为靶向治疗干预提供新的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.