Increased frequency of Foxp3+CD8+ T cells are associated with disease progression during HIV infection.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-03-20 DOI:10.1097/QAD.0000000000004185

Leidan Zhang, Na Chen, Xinyue Wang, Juan Du, Di Wang, Ying Liu, Yuqing Wei, Mengyuan Zhang, Meiju Deng, Meiqing Jiang, Yaxian Kong, Hongxin Zhao

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引用次数: 0

Abstract

Objectives: Recent years have witnessed unprecedented strides in comprehending non-CD4 regulatory T cells (Tregs), such as CD8+ Tregs and double negative T cells (DNT cells), and their role in sustaining immune tolerance and restricting immune activation. This study investigates the role of Foxp3+CD8+ T cells during HIV infection and assess the markers associated with CD4+ Tregs.

Design: This study was designed as a cross-sectional cohort study, comprising 21 age-matched healthy controls (HCs), 122 treatment-naïve participants (TNs), and 60 people living with HIV (PLWH) receiving successful treatment (ARTs).

Methods: The frequency of Foxp3+CD8+ T cells was assessed alongside CD4+ Treg-associated markers and plasma inflammatory factor levels.

Results: Foxp3+CD8+ T cells were enriched in PLWH with CD4+ T cell count < 350 cells/μl and persisted after antiretroviral therapy (ART). Besides, the Foxp3+CD8+T cells were correlated with CD4+ T cell count, CD4/CD8 ratio, and the parameters of activation and systematic inflammation in PLWH. Moreover, Foxp3+CD8+ T cells expressed different levels of Tregs related markers compared to CD4+ Tregs and Foxp3+ DNT cells.

Conclusion: The Foxp3+CD8+T cells are associated with HIV disease progression and employ distinct mechanisms to exert their functions.

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在艾滋病毒感染期间，Foxp3+CD8+ T 细胞频率的增加与疾病进展有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.