{"title":"Microplastics and Impaired Male Reproductive Health - Exploring Biological Pathways of Harm: A Narrative Review.","authors":"Naina Kumar, Mishu Mangla","doi":"10.1093/biolre/ioaf054","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Microplastics (MPs), pervasive environmental pollutants, have emerged as significant health hazards with growing evidence linking them to impaired male reproductive health. MPs can enter the human body through ingestion, inhalation, and dermal absorption, and once internalized, can induce oxidative stress, inflammation, endocrine disruption, and cellular damage leading to impaired male reproductive health. The present narrative review explores the biological pathways through which MPs impair male reproductive health, focusing on their direct and systemic effects.</p><p><strong>Methodology: </strong>A comprehensive literature search spanning up to February 2025 was conducted across electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar. Search terms such as \"microplastic exposure,\" \"male infertility,\" \"male reproductive health\", \"oxidative stress,\" \"endocrine disruption,\" \"spermatogenesis,\" \"inflammation,\" and \"reproductive toxicity\" were employed to identify relevant studies published in peer-reviewed journals, books, and reputable conference proceedings. Inclusion criteria were limited to articles written in English that focused on the biological pathways linking MP exposure to impaired male reproductive health. Priority was given to review articles, original research papers, and meta-analyses. Extracted information was systematically organized to provide a narrative synthesis.</p><p><strong>Conclusion: </strong>Current evidence suggests that MPs may impair male reproductive health through mechanisms like oxidative stress, hormonal disruption, inflammation, and cellular damage. However, the lack of human studies highlights the urgent need for robust research to clarify their impact on human male infertility. Furthermore, this review underscores the necessity for continued research to elucidate molecular mechanisms, inform preventative strategies, and guide regulatory policies addressing MP pollution and its health implications.</p>","PeriodicalId":8965,"journal":{"name":"Biology of Reproduction","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology of Reproduction","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/biolre/ioaf054","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"REPRODUCTIVE BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Microplastics (MPs), pervasive environmental pollutants, have emerged as significant health hazards with growing evidence linking them to impaired male reproductive health. MPs can enter the human body through ingestion, inhalation, and dermal absorption, and once internalized, can induce oxidative stress, inflammation, endocrine disruption, and cellular damage leading to impaired male reproductive health. The present narrative review explores the biological pathways through which MPs impair male reproductive health, focusing on their direct and systemic effects.
Methodology: A comprehensive literature search spanning up to February 2025 was conducted across electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar. Search terms such as "microplastic exposure," "male infertility," "male reproductive health", "oxidative stress," "endocrine disruption," "spermatogenesis," "inflammation," and "reproductive toxicity" were employed to identify relevant studies published in peer-reviewed journals, books, and reputable conference proceedings. Inclusion criteria were limited to articles written in English that focused on the biological pathways linking MP exposure to impaired male reproductive health. Priority was given to review articles, original research papers, and meta-analyses. Extracted information was systematically organized to provide a narrative synthesis.
Conclusion: Current evidence suggests that MPs may impair male reproductive health through mechanisms like oxidative stress, hormonal disruption, inflammation, and cellular damage. However, the lack of human studies highlights the urgent need for robust research to clarify their impact on human male infertility. Furthermore, this review underscores the necessity for continued research to elucidate molecular mechanisms, inform preventative strategies, and guide regulatory policies addressing MP pollution and its health implications.
微塑料(MPs)是普遍存在的环境污染物,已成为严重的健康危害,越来越多的证据表明它们与男性生殖健康受损有关。MPs可通过摄入、吸入和皮肤吸收进入人体,一旦内化,可引起氧化应激、炎症、内分泌紊乱和细胞损伤,从而损害男性生殖健康。目前的叙述回顾探讨了通过MPs损害男性生殖健康的生物学途径,重点是它们的直接和系统影响。方法:对截至2025年2月的电子数据库进行了全面的文献检索,包括PubMed、Scopus、Web of Science和b谷歌Scholar。搜索词如“微塑料暴露”、“男性不育”、“男性生殖健康”、“氧化应激”、“内分泌干扰”、“精子发生”、“炎症”和“生殖毒性”被用来识别发表在同行评审期刊、书籍和知名会议记录上的相关研究。纳入标准仅限于以英文撰写的文章,这些文章侧重于将MP接触与男性生殖健康受损联系起来的生物学途径。优先考虑综述文章、原创研究论文和荟萃分析。提取的信息被系统地组织起来,以提供一种叙事综合。结论:目前的证据表明,MPs可能通过氧化应激、激素紊乱、炎症和细胞损伤等机制损害男性生殖健康。然而,由于缺乏人体研究,迫切需要进行强有力的研究来阐明它们对人类男性不育的影响。此外,这篇综述强调了继续研究的必要性,以阐明分子机制,为预防策略提供信息,并指导针对MP污染及其健康影响的监管政策。
期刊介绍:
Biology of Reproduction (BOR) is the official journal of the Society for the Study of Reproduction and publishes original research on a broad range of topics in the field of reproductive biology, as well as reviews on topics of current importance or controversy. BOR is consistently one of the most highly cited journals publishing original research in the field of reproductive biology.