{"title":"Diverse roles of stress-responsive RNP granules in oogenesis and infertility.","authors":"M Rebecca Glineburg, Carolee Nguyen","doi":"10.1093/biolre/ioaf057","DOIUrl":null,"url":null,"abstract":"<p><p>Effectively responding to cellular stress (e.g. nutrient deprivation, oxidative stress) is essential for cell and organismal survival. A protective mechanism is especially critical in developing oocytes, where a prolonged quiescent state and the inability to divide render oocytes highly susceptible to accumulating stress that can result in cell death if unaddressed. Despite the common view that stress granules are the primary stress-responsive ribonucleoprotein (RNP) granule, accumulating evidence shows that in ovaries, other RNP granules also uniquely mediate gene regulation in response to stress. Here we review recent insights into RNP granule dynamics and RNP granule protein function during stress in the context of oogenesis among both invertebrates and vertebrates, with an emphasis on insights from Drosophila and mice. We also discuss roles for stress-responsive RNPs in maintaining stem cell populations, and complicating fertility treatments. By exploring how stress-induced RNP dynamics can impact oogenesis, both positively and negatively, we can better understand how stress contributes to reduced fecundity and infertility. We conclude by offering key research questions that can drive the next generation of insights.</p>","PeriodicalId":8965,"journal":{"name":"Biology of Reproduction","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology of Reproduction","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/biolre/ioaf057","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"REPRODUCTIVE BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Effectively responding to cellular stress (e.g. nutrient deprivation, oxidative stress) is essential for cell and organismal survival. A protective mechanism is especially critical in developing oocytes, where a prolonged quiescent state and the inability to divide render oocytes highly susceptible to accumulating stress that can result in cell death if unaddressed. Despite the common view that stress granules are the primary stress-responsive ribonucleoprotein (RNP) granule, accumulating evidence shows that in ovaries, other RNP granules also uniquely mediate gene regulation in response to stress. Here we review recent insights into RNP granule dynamics and RNP granule protein function during stress in the context of oogenesis among both invertebrates and vertebrates, with an emphasis on insights from Drosophila and mice. We also discuss roles for stress-responsive RNPs in maintaining stem cell populations, and complicating fertility treatments. By exploring how stress-induced RNP dynamics can impact oogenesis, both positively and negatively, we can better understand how stress contributes to reduced fecundity and infertility. We conclude by offering key research questions that can drive the next generation of insights.
期刊介绍:
Biology of Reproduction (BOR) is the official journal of the Society for the Study of Reproduction and publishes original research on a broad range of topics in the field of reproductive biology, as well as reviews on topics of current importance or controversy. BOR is consistently one of the most highly cited journals publishing original research in the field of reproductive biology.