Diverse roles of stress-responsive RNP granules in oogenesis and infertility.

IF 3.1 2区 生物学 Q2 REPRODUCTIVE BIOLOGY
M Rebecca Glineburg, Carolee Nguyen
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引用次数: 0

Abstract

Effectively responding to cellular stress (e.g. nutrient deprivation, oxidative stress) is essential for cell and organismal survival. A protective mechanism is especially critical in developing oocytes, where a prolonged quiescent state and the inability to divide render oocytes highly susceptible to accumulating stress that can result in cell death if unaddressed. Despite the common view that stress granules are the primary stress-responsive ribonucleoprotein (RNP) granule, accumulating evidence shows that in ovaries, other RNP granules also uniquely mediate gene regulation in response to stress. Here we review recent insights into RNP granule dynamics and RNP granule protein function during stress in the context of oogenesis among both invertebrates and vertebrates, with an emphasis on insights from Drosophila and mice. We also discuss roles for stress-responsive RNPs in maintaining stem cell populations, and complicating fertility treatments. By exploring how stress-induced RNP dynamics can impact oogenesis, both positively and negatively, we can better understand how stress contributes to reduced fecundity and infertility. We conclude by offering key research questions that can drive the next generation of insights.

应激反应性RNP颗粒在卵子发生和不孕症中的多种作用。
有效应对细胞应激(如营养剥夺、氧化应激)对细胞和生物体的生存至关重要。保护机制在卵母细胞发育过程中尤为重要,卵母细胞处于长时间的静止状态,无法分裂,这使得卵母细胞极易受到累积的压力,如果不加以处理,可能导致细胞死亡。尽管人们普遍认为应激颗粒是主要的应激反应核糖核蛋白(RNP)颗粒,但越来越多的证据表明,在卵巢中,其他RNP颗粒也独特地介导了应激反应的基因调控。在这里,我们回顾了在无脊椎动物和脊椎动物中,RNP颗粒动力学和RNP颗粒蛋白功能在应激条件下的最新见解,重点是来自果蝇和小鼠的见解。我们还讨论了应激反应性RNPs在维持干细胞群和使生育治疗复杂化方面的作用。通过探索压力诱导的RNP动态如何影响卵子发生,无论是积极的还是消极的,我们可以更好地理解压力是如何导致生育能力降低和不育的。最后,我们提出了可以推动下一代见解的关键研究问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology of Reproduction
Biology of Reproduction 生物-生殖生物学
CiteScore
6.30
自引率
5.60%
发文量
214
审稿时长
1 months
期刊介绍: Biology of Reproduction (BOR) is the official journal of the Society for the Study of Reproduction and publishes original research on a broad range of topics in the field of reproductive biology, as well as reviews on topics of current importance or controversy. BOR is consistently one of the most highly cited journals publishing original research in the field of reproductive biology.
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