Biomaterials in Relative Devices for Traumatic Cataract: Recent Advances and Future Perspectives.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-03-20 DOI:10.1021/acsbiomaterials.4c02117

Si-Ting Sheng, Xing-Di Wu, Jing-Wei Xu, Zhe Xu, Shuang Ni, Wen Xu, Zhi-Kang Xu

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引用次数: 0

Abstract

Ocular trauma deprives one of the vision for high-quality life. Management of a traumatic cataract requires extensive surgical experience with a range of biomaterials and biomedical devices including intraocular lenses (IOLs), capsular tension rings (CTRs), prosthetic iris (PSI) implants, bandage contact lenses (BCLs), artificial corneas (ACs), and surgical sutures. Numerous demands, involving biocompatibility, cell toxicity, processability, mechanical strength, toughness/flexibility, transparency/opacity, hydrophilicity/hydrophobicity, and stability/biodegradability, are widely considered for fabricating these biomaterials and devices. Furthermore, a multifunction including drug-release and photothermal therapy is also endearing to those biomaterials in IOLs, CTRs, BCLs, and surgical sutures for anti-inflammational and antibacterial characteristics during traumatic cataract treatments. More recently, 3D printing has been demonstrated to effectively fabricate PSI and ACs with complex shapes to meet the personal requirements of patients. We summarize the main principles and the recent achievements of these advances. We also suggest the potential directions for their future development and discuss the remaining challenges.

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture