Weakly Charged Analyte Concentration Scenarios Near an Ion-selective Microparticle

IF 1.3 4区工程技术 Q2 ENGINEERING, AEROSPACE

Microgravity Science and Technology Pub Date : 2025-03-22 DOI:10.1007/s12217-025-10172-w

Georgy S. Ganchenko, Maxim S. Alekseev, Vladimir S. Shelistov, Evgeny A. Demekhin

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Abstract

The work presents the results of numerical simulations of a microdevice designed to concentrate a low-concentration analyte consisting of weakly charged macromolecules. The microdevice consists of a spherical chamber containing an ion-selective sphere located in the center. A gravity-induced pressure-driven flow of an electrolyte solution containing the analyte is established through the chamber. Two electrodes are placed at the input and output of the device to create an external electric field. The properties of the analyte typically differ from those of the ions in the buffer electrolyte solution; for instance, its diffusion coefficient is normally much smaller than those of the electrolyte ions. This asymmetry, combined with a nontrivial electroosmotic flow along the ion-selective sphere, results in significant differences in the analyte behavior compared with the behavior of ions. Several scenarios of analyte concentration, based on both its intrinsic properties (different diffusion coefficients and charges) and external factors such as the intensity of an external electric field and the properties of the flow, are investigated.

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离子选择性微粒子附近的弱电荷分析物浓度情景

这项研究介绍了一种微型装置的数值模拟结果，该装置旨在浓缩由弱电荷大分子组成的低浓度分析物。该微型装置由一个球形腔体组成，腔体中心有一个离子选择球。在重力作用下，含有分析物的电解质溶液在压力驱动下流经球室。在设备的输入和输出端放置两个电极，以产生外部电场。分析物的特性通常与缓冲电解质溶液中离子的特性不同；例如，分析物的扩散系数通常比电解质离子的扩散系数小得多。这种不对称性，再加上沿着离子选择球的非微量电渗流，导致分析物的行为与离子的行为存在显著差异。根据分析物的内在特性（不同的扩散系数和电荷）和外部因素（如外部电场强度和流动特性），研究了分析物浓度的几种情况。

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来源期刊

Microgravity Science and Technology 工程技术-工程：宇航

CiteScore

3.50

自引率

44.40%

发文量

期刊介绍： Microgravity Science and Technology – An International Journal for Microgravity and Space Exploration Related Research is a is a peer-reviewed scientific journal concerned with all topics, experimental as well as theoretical, related to research carried out under conditions of altered gravity. Microgravity Science and Technology publishes papers dealing with studies performed on and prepared for platforms that provide real microgravity conditions (such as drop towers, parabolic flights, sounding rockets, reentry capsules and orbiting platforms), and on ground-based facilities aiming to simulate microgravity conditions on earth (such as levitrons, clinostats, random positioning machines, bed rest facilities, and micro-scale or neutral buoyancy facilities) or providing artificial gravity conditions (such as centrifuges). Data from preparatory tests, hardware and instrumentation developments, lessons learnt as well as theoretical gravity-related considerations are welcome. Included science disciplines with gravity-related topics are: − materials science − fluid mechanics − process engineering − physics − chemistry − heat and mass transfer − gravitational biology − radiation biology − exobiology and astrobiology − human physiology