Galina A. Ryltseva, Alexey E. Dudaev, Sergei Y. Lipaikin, Fares D. E. Ghorabe, Natalia G. Menzyanova, Sviatlana A. Ulasevich, Ekaterina V. Skorb, Tatiana G. Volova, Ekaterina I. Shishatskaya
{"title":"The Interactions Between Polyhydroxyalkanoates and Cells Involved in the Process of Tissue Damage Repair","authors":"Galina A. Ryltseva, Alexey E. Dudaev, Sergei Y. Lipaikin, Fares D. E. Ghorabe, Natalia G. Menzyanova, Sviatlana A. Ulasevich, Ekaterina V. Skorb, Tatiana G. Volova, Ekaterina I. Shishatskaya","doi":"10.1007/s10924-025-03513-8","DOIUrl":null,"url":null,"abstract":"<div><p>The control of the surface topography of biomaterials is a key factor for the management of post-implantation recovery processes. The study of the influence of the nanorelief of polyhydroxyalkanoate (PHA) films on the functional state of cells involved in tissue healing process is important for the development of biocompatible materials for tissue engineering. In this work, polymer films based on polyhydroxyalkanoates of various compositions with different surface relief were analyzed. The effect of the nanorelief of PHA films on the morphology, adhesion and proliferation of cells involved in regenerative processes in tissue damage (erythrocytes, macrophages, fibroblasts) was evaluated. According to the obtained results, it was found that all films samples based on polyhydroxyalkanoates of various compositions have high biocompatibility and do not cause any pronounced negative cellular reactions. However, differences in cell morphology, adhesion, and proliferation were noted between film samples. In the case of P3HB films, a slight activation of local inflammatory reactions was noted. Thus, P3HB matrix is less preferable for use in restoration of soft tissues. On the other hand, films based on P3HB3HV demonstrated high biocompatibility, which allows to conclude that this copolymer matrix is promising for use in tissue engineering.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"1984 - 2000"},"PeriodicalIF":4.7000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymers and the Environment","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10924-025-03513-8","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
The control of the surface topography of biomaterials is a key factor for the management of post-implantation recovery processes. The study of the influence of the nanorelief of polyhydroxyalkanoate (PHA) films on the functional state of cells involved in tissue healing process is important for the development of biocompatible materials for tissue engineering. In this work, polymer films based on polyhydroxyalkanoates of various compositions with different surface relief were analyzed. The effect of the nanorelief of PHA films on the morphology, adhesion and proliferation of cells involved in regenerative processes in tissue damage (erythrocytes, macrophages, fibroblasts) was evaluated. According to the obtained results, it was found that all films samples based on polyhydroxyalkanoates of various compositions have high biocompatibility and do not cause any pronounced negative cellular reactions. However, differences in cell morphology, adhesion, and proliferation were noted between film samples. In the case of P3HB films, a slight activation of local inflammatory reactions was noted. Thus, P3HB matrix is less preferable for use in restoration of soft tissues. On the other hand, films based on P3HB3HV demonstrated high biocompatibility, which allows to conclude that this copolymer matrix is promising for use in tissue engineering.
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
