Regioselective Synthesis of β,γ-Unsaturated Amides from Unactivated Alkenes

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-03-08 DOI:10.1021/acs.joc.5c0009310.1021/acs.joc.5c00093

Sabela Vega-Ces, Bogdan R. Brutiu, Daniel Kaiser and Nuno Maulide*,

引用次数: 0

Abstract

β,γ-Unsaturated amides are valuable substrates for downstream functionalization reactions but can be challenging to prepare. Herein, we introduce an approach featuring the regioselective addition of carbamoyl chlorides to unactivated alkenes, present its scope and limitations, and exemplify its synthetic utility.

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未活化烯烃区域选择性合成β，γ-不饱和酰胺

β，γ-不饱和酰胺是下游功能化反应的重要底物，但其制备具有挑战性。在此，我们介绍了一种具有区域选择性的碳氨甲酰氯加成到非活化烯烃的方法，介绍了它的范围和局限性，并举例说明了它的合成用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.