Blue‐Light‐Induced Stereoselective Synthesis of α‐Alkylated Amino Acid Derivatives

Abstract

A photoredox‐catalyzed decarboxylative C(sp³)−H alkylation of glycine derivatives, utilizing (+)/(−)‐camphorsultam as a chiral auxiliary and alkyl N‐hydroxyphthalimide (NHP) ester as a radical precursor, has been developed, providing an efficient approach for the stereoselective synthesis of valuable enantioenriched unnatural α‐alkylated amino acid derivatives. The methodology operates under mild conditions, demonstrates broad substrate tolerance, and exhibits excellent stereoselectivity. Preliminary mechanistic investigations indicate that the reaction proceeds via a radical pathway.