Long-term exposure to dust in fine particulate matter and post-stroke functional impairment—Findings from the China National Stroke Screening Surveys

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-03-20 DOI:10.1016/j.jhazmat.2025.137979

Zhaoyang Pan, Xueyan Han, Man Cao, Ruohan Wang, Jian Guo, Wei Sun, Jiarun Mi, Yuanli Liu, Tao Xue, Tianjia Guan

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引用次数: 0

Abstract

The dust component of particulate matter (PM) warrants more attention in the era of climate change and increased frequency of dust event, yet rarely are studies focused exclusively on the long-term health effects of dust PM_2.5. This study aims to assess the relative toxicity of dust and non-dust PM_2.5 on the long-term functional impairment after stroke. We utilized data from a multicenter, national survey in China from 2013 to 2019 and selected participants with repeated assessments of the functional impairment outcomes, the modified Rankin scale (mRS) score, to form a longitudinal dataset. The dust PM_2.5 exposure data were constructed by combining multiple sources and of high spatial resolution. Fixed effect models were used to estimate the association between dust PM_2.5 exposure and changes in mRS scores. A two-dimensional spline model was used to model the joint effect of dust and non-dust PM_2.5 exposure. We included 28,081 participants (65,883 visits). Per interquartile range increase of the dust PM_2.5 was associated with 0.048 (95% confidence interval [CI]: 0.003-0.092) increase in mRS score. Results of co-exposure to dust and non-dust PM_2.5 showed that the greater the proportion of dust PM_2.5 was, the stronger the combined effect. This study revealed that long-term exposure to dust PM_2.5 was associated with post-stroke functional impairment. More studies on the long-term effects of dust and dust-sourced PM_2.5 on neurological outcomes are warranted in the future.

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.