Assessing brain vascular impairment, white matter lesions and ApoE status as predictors of behavioral and psychological symptoms of dementia (BPSD) in a multicentre sample of patients with Alzheimer's disease: a multidisciplinary retrospective study.

Annali dell'Istituto superiore di sanita Pub Date : 2025-01-01 DOI:10.4415/ANN_25_01_06

Luana Vaianella, Raffaele Bove, Alessandro Giuliani, Valentina Pavino, Valeria Guglielmi, Gianmarco Giacomini, Concettina Rossi, Maria Carla Massimetti, Cesare Iani, Alessandra Bizzarro

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引用次数: 0

Abstract

Background: Understanding pathogenetic background and risk factors is the primary step to a better behavioral and psychological symptoms of dementia (BPSD) management. To this aim, this exploratory study is designed to sketch some indicative correlations between BPSD severity and vascular, genetic and cognitive variables.

Methods: A retrospective cross-sectional study conducted on medical reports of 135 Alzheimer Dementia (AD) patients from two memory clinics. Each subject underwent clinical examination and brain Magnetic Resonance Imaging (MRI), mini mental state examination (MMSE) and behavioral assessment using the neuropsychiatric inventory (NPI). This real-world cross-sectional study aimed to correlate the load of white matter lesions and global vascular compromise with clinical assessment. In addition, apolipoprotein E (ApoE) genotype was checked in 92 patients. Data were analysed performing Spearman correlation and principal component analysis (PCA).

Results: BPSD severity was independent from cognitive impairment, vascular impairment, white matter lesions and ApoE status.

Conclusions: Our results do not confirm the possible role for vascular impairment in BPSD severity as previously reported. Studies focusing on different biological features in relation to other structural, psychosocial and environmental factors are needed in order to get a more reliable model.

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在多中心阿尔茨海默病患者样本中评估脑血管损伤、白质病变和ApoE状态作为痴呆（BPSD）行为和心理症状的预测因素：一项多学科回顾性研究

背景：了解痴呆的发病背景和危险因素是更好地管理BPSD行为和心理症状的首要步骤。为此，本探索性研究旨在概述BPSD严重程度与血管、遗传和认知变量之间的一些指示性相关性。方法：对来自两家记忆诊所的135例阿尔茨海默氏痴呆（AD）患者的医学报告进行回顾性横断面研究。每名受试者均接受临床检查、脑磁共振成像（MRI）、迷你精神状态检查（MMSE）和神经精神量表（NPI）的行为评估。这项真实世界的横断面研究旨在将白质病变负荷和整体血管损害与临床评估联系起来。此外，对92例患者进行了载脂蛋白E （ApoE）基因型检测。采用Spearman相关和主成分分析（PCA）对数据进行分析。结果：BPSD严重程度与认知功能障碍、血管功能障碍、白质病变和ApoE水平无关。结论：我们的研究结果不像之前报道的那样证实血管损伤在BPSD严重程度中的可能作用。为了获得更可靠的模型，需要关注与其他结构、社会心理和环境因素相关的不同生物学特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annali dell'Istituto superiore di sanita

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