Therapeutic efficacy of transcranial direct current stimulation in treating auditory hallucinations in schizophrenia: A meta-analysis.

IF 3.9 4区 医学 Q1 PSYCHIATRY
Shi-Jia Zou, Jin-Nan Shi
{"title":"Therapeutic efficacy of transcranial direct current stimulation in treating auditory hallucinations in schizophrenia: A meta-analysis.","authors":"Shi-Jia Zou, Jin-Nan Shi","doi":"10.5498/wjp.v15.i3.99364","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia is a chronic psychiatric condition with complex symptomatology, including debilitating auditory hallucinations. Transcranial direct current stimulation (tDCS) has been explored as an adjunctive treatment to alleviate such symptoms.</p><p><strong>Aim: </strong>To evaluate the therapeutic efficacy of tDCS in schizophrenia.</p><p><strong>Methods: </strong>Adhering to PRISMA guidelines, we systematically searched PubMed, Embase, Web of Science, and the Cochrane Library on September 19, 2023, for randomized controlled trials examining the efficacy of tDCS in schizophrenia, with no language or time restrictions. We included studies that compared tDCS with a control condition and reported clinically relevant outcomes. Data extraction and quality assessments were performed by independent evaluators using the Cochrane Collaboration's risk of bias tool. Statistical heterogeneity was evaluated, and a random-effects model was applied due to moderate heterogeneity (<i>I</i> <sup>2</sup> = 41.3%).</p><p><strong>Results: </strong>Nine studies comprising 425 participants (tDCS group: 219, control group: 206) were included. The meta-analysis demonstrated a significant reduction in auditory hallucination scores following tDCS treatment (weighted mean difference: -2.18, 95% confidence interval: -4.0 to -0.29, <i>P</i> < 0.01). Sensitivity analysis confirmed the robustness of the results, with no significant influence from individual studies. Additionally, publication bias was not detected, supporting the reliability and generalizability of the findings. These results underscore the efficacy of tDCS as a therapeutic intervention for auditory hallucinations in schizophrenia.</p><p><strong>Conclusion: </strong>tDCS significantly reduces auditory hallucinations in schizophrenia, suggesting its potential as an effective adjunctive treatment for managing this disabling symptom. The findings highlight the practical significance of tDCS in clinical settings, particularly for patients with treatment-resistant auditory hallucinations.</p>","PeriodicalId":23896,"journal":{"name":"World Journal of Psychiatry","volume":"15 3","pages":"99364"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886339/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5498/wjp.v15.i3.99364","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Schizophrenia is a chronic psychiatric condition with complex symptomatology, including debilitating auditory hallucinations. Transcranial direct current stimulation (tDCS) has been explored as an adjunctive treatment to alleviate such symptoms.

Aim: To evaluate the therapeutic efficacy of tDCS in schizophrenia.

Methods: Adhering to PRISMA guidelines, we systematically searched PubMed, Embase, Web of Science, and the Cochrane Library on September 19, 2023, for randomized controlled trials examining the efficacy of tDCS in schizophrenia, with no language or time restrictions. We included studies that compared tDCS with a control condition and reported clinically relevant outcomes. Data extraction and quality assessments were performed by independent evaluators using the Cochrane Collaboration's risk of bias tool. Statistical heterogeneity was evaluated, and a random-effects model was applied due to moderate heterogeneity (I 2 = 41.3%).

Results: Nine studies comprising 425 participants (tDCS group: 219, control group: 206) were included. The meta-analysis demonstrated a significant reduction in auditory hallucination scores following tDCS treatment (weighted mean difference: -2.18, 95% confidence interval: -4.0 to -0.29, P < 0.01). Sensitivity analysis confirmed the robustness of the results, with no significant influence from individual studies. Additionally, publication bias was not detected, supporting the reliability and generalizability of the findings. These results underscore the efficacy of tDCS as a therapeutic intervention for auditory hallucinations in schizophrenia.

Conclusion: tDCS significantly reduces auditory hallucinations in schizophrenia, suggesting its potential as an effective adjunctive treatment for managing this disabling symptom. The findings highlight the practical significance of tDCS in clinical settings, particularly for patients with treatment-resistant auditory hallucinations.

经颅直流电刺激治疗精神分裂症患者幻听的疗效:荟萃分析。
背景:精神分裂症是一种具有复杂症状的慢性精神疾病,包括使人衰弱的幻听。经颅直流电刺激(tDCS)已被探索作为一种辅助治疗来缓解这些症状。目的:评价tDCS治疗精神分裂症的疗效。方法:遵循PRISMA指南,我们于2023年9月19日系统地检索PubMed、Embase、Web of Science和Cochrane Library,在没有语言和时间限制的情况下,对tDCS治疗精神分裂症的疗效进行随机对照试验。我们纳入了将tDCS与对照条件进行比较并报告临床相关结果的研究。数据提取和质量评估由独立评估人员使用Cochrane协作的偏倚风险工具进行。评估统计异质性,由于异质性中等(I 2 = 41.3%),采用随机效应模型。结果:纳入9项研究,共纳入425名受试者(tDCS组219名,对照组206名)。meta分析显示,tDCS治疗后幻听评分显著降低(加权平均差值:-2.18,95%可信区间:-4.0 ~ -0.29,P < 0.01)。敏感性分析证实了结果的稳健性,没有受到个别研究的显著影响。此外,未发现发表偏倚,支持研究结果的可靠性和普遍性。这些结果强调了tDCS作为一种治疗精神分裂症幻听的干预手段的有效性。结论:tDCS可显著减少精神分裂症患者的幻听,提示其作为治疗这种致残症状的有效辅助治疗的潜力。研究结果强调了tDCS在临床环境中的实际意义,特别是对治疗难治性幻听患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
6.50%
发文量
110
期刊介绍: The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信