{"title":"Ditans and Gepants: hope or false promise for menstrual migraine?","authors":"Gonçalo Cabral","doi":"10.1007/s10072-025-08121-x","DOIUrl":null,"url":null,"abstract":"<p><p>Menstrual migraine (MM) is a debilitating migraine subtype associated with hormonal fluctuations, often resistant to conventional treatments. Gepants, novel calcitonin generelated peptide (CGRP) receptor antagonists, and ditans, serotonin 5-HT1F receptor agonists, offer potential alternatives to triptans due to their non-vasoconstrictive properties. However, evidence supporting their effectiveness in MM remains limited. While studies suggest gepants may reduce perimenstrual migraine severity and ditans provide acute relief, their overall efficacy compared to triptans remains uncertain. Cost and side effect profiles further complicate their widespread adoption. This letter discusses the current state of evidence for gepants and ditans in MM, highlighting the need for further large-scale, real-world studies to clarify their role in treatment strategies.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10072-025-08121-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Menstrual migraine (MM) is a debilitating migraine subtype associated with hormonal fluctuations, often resistant to conventional treatments. Gepants, novel calcitonin generelated peptide (CGRP) receptor antagonists, and ditans, serotonin 5-HT1F receptor agonists, offer potential alternatives to triptans due to their non-vasoconstrictive properties. However, evidence supporting their effectiveness in MM remains limited. While studies suggest gepants may reduce perimenstrual migraine severity and ditans provide acute relief, their overall efficacy compared to triptans remains uncertain. Cost and side effect profiles further complicate their widespread adoption. This letter discusses the current state of evidence for gepants and ditans in MM, highlighting the need for further large-scale, real-world studies to clarify their role in treatment strategies.
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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