Assessing weight change in adolescents and young adults with perinatally acquired HIV and integrase inhibitor use.

IF 2.8 3区 医学 Q2 INFECTIOUS DISEASES
HIV Medicine Pub Date : 2025-03-20 DOI:10.1111/hiv.70019
Kathleen J Pincus, Nabila Faridi, Patrick Amadeus Ryscavage, Hyunuk Seung, Kristine A Parbuoni, Matthew Grant, Neha Sheth Pandit
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Abstract

Introduction: Integrase strand transfer inhibitors (INSTIs) are the mainstay of treatment in adults and children living with HIV. Weight gain has been associated with INSTI use in adults; however, less data exist on its effects on younger patients. This study aimed to characterize the impact of INSTIs on weight in patients living with perinatally acquired HIV (PAHIV).

Methods: Retrospective cohort study of patients with PAHIV maintained on an INSTI for ≥6 months. Descriptive statistics were used to illustrate baseline characteristics. A linear mixed model with spline at the time of INSTI initiation was used to evaluate the primary outcome of the change in body mass index (BMI) slope pre- and post-INSTI use.

Results: Ninety-three patients with PAHIV who initiated INSTIs between June 2010 and September 2021 were included. The median age of INSTI initiation was 19.3 (±5.9) years. Before INSTI initiation, BMI showed a positive trend of 0.11 kg/m2 per 6 months (p = 0.2); after INSTI initiation, it increased by 0.26 kg/m2 per 6 months (p = 0.002). Although similar post-INSTI BMI increases were seen regardless of age at initiation, a significant BMI change was seen post-INSTI initiation in females, those on concomitant tenofovir alafenamide or other medications that cause weight gain, with baseline BMIs of underweight or healthy weight, bictegravir or dolutegravir exposure and those virologically suppressed at initiation.

Conclusion: In this US cohort of patients with PAHIV initiated on INSTI, a sustained increase in the rate of BMI change was observed. Specific patient variables resulted in a statistically significant increase in weight gain after INSTI initiation.

评估围产期获得性HIV的青少年和年轻人体重变化和整合酶抑制剂的使用。
整合酶链转移抑制剂(iniss)是治疗成人和儿童艾滋病毒感染者的主要药物。体重增加与成人使用INSTI有关;然而,关于其对年轻患者的影响的数据较少。本研究旨在描述iniss对围产期获得性HIV (PAHIV)患者体重的影响。方法:回顾性队列研究的PAHIV患者维持在INSTI≥6个月。描述性统计用于说明基线特征。采用样条线性混合模型评价使用INSTI前后身体质量指数(BMI)斜率变化的主要结果。结果:纳入了2010年6月至2021年9月期间启动inins的93例PAHIV患者。INSTI起始的中位年龄为19.3(±5.9)岁。在INSTI开始前,BMI呈上升趋势,为0.11 kg/m2 / 6个月(p = 0.2);启动INSTI后,每6个月增加0.26 kg/m2 (p = 0.002)。尽管与开始注射时的年龄无关,注射后的BMI都出现了类似的增加,但在女性、同时服用替诺福韦或其他导致体重增加的药物、基线BMI为体重不足或健康体重、暴露于比替替韦或多替替韦以及开始注射时病毒学抑制的女性中,发现了显著的BMI变化。结论:在这个接受INSTI治疗的PAHIV患者的美国队列中,观察到BMI变化率的持续增加。特定的患者变量导致INSTI开始后体重增加的统计显著增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
HIV Medicine
HIV Medicine 医学-传染病学
CiteScore
5.10
自引率
10.00%
发文量
167
审稿时长
6-12 weeks
期刊介绍: HIV Medicine aims to provide an alternative outlet for publication of international research papers in the field of HIV Medicine, embracing clinical, pharmocological, epidemiological, ethical, preclinical and in vitro studies. In addition, the journal will commission reviews and other feature articles. It will focus on evidence-based medicine as the mainstay of successful management of HIV and AIDS. The journal is specifically aimed at researchers and clinicians with responsibility for treating HIV seropositive patients.
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