Circadian Biology in Obstructive Sleep Apnea-Associated Cardiovascular Disease

IF 4.9 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of molecular and cellular cardiology Pub Date : 2025-03-17 DOI:10.1016/j.yjmcc.2025.03.008

Laetitia S. Gaspar , Santoshi Pyakurel , Na Xu , Shane P. D'Souza , Bala S.C. Koritala

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Abstract

A dysregulated circadian system is independently associated with both Obstructive Sleep Apnea (OSA) and cardiovascular disease (CVD). OSA and CVD coexistence is often seen in patients with prolonged untreated OSA. However, the role of circadian dysregulation in their relationship is unclear. Half of the human genes, associated biological pathways, and physiological functions exhibit circadian rhythms, including blood pressure and heart rate regulation. Mechanisms related to circadian dysregulation and heart function are potentially involved in the coexistence of OSA and CVD. In this article, we provide a comprehensive overview of circadian dysregulation in OSA and associated CVD. We also discuss feasible animal models and new avenues for future research to understand their relationship. Oxygen-sensing pathways, inflammation, dysregulation of cardiovascular processes, oxidative stress, metabolic regulation, hormone signaling, and epigenetics are potential clock-regulated mechanisms connecting OSA and CVD.

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阻塞性睡眠呼吸暂停相关心血管疾病的昼夜生物学研究

昼夜节律系统失调与阻塞性睡眠呼吸暂停（OSA）和心血管疾病（CVD）独立相关。OSA和CVD共存常见于长期未经治疗的OSA患者。然而，昼夜节律失调在两者关系中的作用尚不清楚。一半的人类基因、相关的生物途径和生理功能表现出昼夜节律，包括血压和心率调节。与昼夜节律失调和心脏功能相关的机制可能与OSA和CVD共存有关。在这篇文章中，我们提供了OSA和相关CVD的昼夜节律失调的全面概述。我们还讨论了可行的动物模型和未来研究的新途径，以了解它们之间的关系。氧感应途径、炎症、氧化应激、代谢调节、激素信号和表观遗传学是连接OSA和CVD的潜在时钟调节机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of molecular and cellular cardiology 医学-细胞生物学

CiteScore

10.70

自引率

0.00%

发文量

171

审稿时长

42 days

期刊介绍： The Journal of Molecular and Cellular Cardiology publishes work advancing knowledge of the mechanisms responsible for both normal and diseased cardiovascular function. To this end papers are published in all relevant areas. These include (but are not limited to): structural biology; genetics; proteomics; morphology; stem cells; molecular biology; metabolism; biophysics; bioengineering; computational modeling and systems analysis; electrophysiology; pharmacology and physiology. Papers are encouraged with both basic and translational approaches. The journal is directed not only to basic scientists but also to clinical cardiologists who wish to follow the rapidly advancing frontiers of basic knowledge of the heart and circulation.