Feasibility of magnetic resonance elastography in the healthy rat heart.

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2025-03-19 DOI:10.1002/mrm.30504

Lisa Smith, Vidar Magne Skulberg, Lili Zhang, Ivar Sjaastad, Emil Knut Stenersen Espe

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引用次数: 0

Abstract

Purpose: Develop a MR elastography (MRE) protocol to detect in vivo cardiac stiffness in rats.

Methods: This study was approved by the National Animal Research Authority. A healthy, adult, male Sprague-Dawley rat underwent cardiac MRE. A specialized direct shaking cardiac MRE setup and MRI protocol were designed. Stiffness was measured at 15 cardiac phases. A single midventricular slice was acquired, and intrasession variability was measured. A direct inversion of the Helmholtz equation was used to calculate the stiffness from MRE images.

Results: In the healthy rat, the early systolic stiffness was 2.90 kPa. The stiffness increased to the end systole (3.81 kPa), followed by a reduction during diastole to 2.61 kPa. The intrasession correlation was ρ = 0.88 (p < 0.001).

Conclusion: This study demonstrates the feasibility of cardiac MRE in rats. Our results confirm that cardiac stiffness increases from early systole to end systole, followed by a decrease in diastole.

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磁共振弹性成像在健康大鼠心脏中的可行性。

目的：建立一种磁共振弹性成像（MRE）方法来检测大鼠体内心脏僵硬度。方法：本研究经国家动物研究局批准。一只健康的成年雄性Sprague-Dawley大鼠进行了心脏磁共振。设计了一种专门的直摇心脏MRE装置和MRI方案。在15个心相时测量僵硬度。获得单个中心室切片，并测量内切变异性。采用直接反演亥姆霍兹方程的方法，从MRE图像中计算刚度。结果：健康大鼠早期收缩刚度为2.90 kPa。在收缩期末期（3.81 kPa）刚度增加，随后在舒张期降低至2.61 kPa。实验组内相关系数ρ = 0.88 (p)。结论：本研究证实了大鼠心脏MRE的可行性。我们的研究结果证实，心脏硬度从收缩期早期到收缩期末期增加，随后是舒张期减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.