Spatial immune remodeling of the liver metastases: discovering the path to antimetastatic therapy.

IF 10.3 1区医学 Q1 IMMUNOLOGY

Journal for Immunotherapy of Cancer Pub Date : 2025-03-18 DOI:10.1136/jitc-2024-011002

Wenchao Xu, Yibo Wang, Nanzhou Wang, Jianzhou Liu, Li Zhou, Junchao Guo

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Abstract

The intrinsic characteristics of metastatic tumors are of great importance in terms of the development of antimetastatic treatment strategies. Elucidation from a spatial immune perspective has the potential to provide a more comprehensive understanding of the mechanisms underlying immune escape, effectively addressing the limitations of relying solely on the analysis of immune cell subpopulation transcriptional profiles. Advances in spatial omics technology enable researchers to precisely analyze precious liver metastasis samples in a high-throughput manner, revealing spatial alterations in immune cell distribution induced by metastasis and exploring the molecular basis of the remodeling process. The aggregation of specific cell subpopulations in distinct regions not only modifies local immune characteristics but also concurrently affects global biological behaviors of liver metastatic tumors. Identifying specific spatial immune characteristics in pretreatment or early-stage treatment tissue samples may achieve accurate clinical predictions. Moreover, developing strategies that target spatial immune remodeling is a promising avenue for future antimetastatic therapy.

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肝转移的空间免疫重构：发现抗转移治疗的途径。

转移性肿瘤的内在特征对于制定抗转移治疗策略具有重要意义。从空间免疫角度的阐明有可能提供对免疫逃逸机制的更全面理解，有效地解决仅依赖免疫细胞亚群转录谱分析的局限性。空间组学技术的进步使研究人员能够以高通量的方式精确分析宝贵的肝转移样本，揭示转移引起的免疫细胞分布的空间变化，探索重塑过程的分子基础。特定细胞亚群在不同区域的聚集不仅改变了局部免疫特性，而且同时影响了肝转移瘤的整体生物学行为。在预处理或早期治疗组织样本中识别特定的空间免疫特征可以实现准确的临床预测。此外，开发针对空间免疫重塑的策略是未来抗转移治疗的一个有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal for Immunotherapy of Cancer Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

17.70

自引率

4.60%

发文量

522

审稿时长

18 weeks

期刊介绍： The Journal for ImmunoTherapy of Cancer (JITC) is a peer-reviewed publication that promotes scientific exchange and deepens knowledge in the constantly evolving fields of tumor immunology and cancer immunotherapy. With an open access format, JITC encourages widespread access to its findings. The journal covers a wide range of topics, spanning from basic science to translational and clinical research. Key areas of interest include tumor-host interactions, the intricate tumor microenvironment, animal models, the identification of predictive and prognostic immune biomarkers, groundbreaking pharmaceutical and cellular therapies, innovative vaccines, combination immune-based treatments, and the study of immune-related toxicity.