Longitudinal quality of life assessment after laparoscopic colorectal cancer surgery using the Gastrointestinal Quality of Life Index questionnaire: A multicentre prospective study

IF 2.9 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Colorectal Disease Pub Date : 2025-03-20 DOI:10.1111/codi.70060

Tae-Gyun Lee, Seung-Bum Ryoo, Heung-Kwon Oh, Yong Beom Cho, Chang Hyun Kim, Ju Hyun Lee, Hong-Min Ahn, Hye-Rim Shin, Mi Jeong Choi, Min Hyeong Jo, Duck-Woo Kim, Sung-Bum Kang

{"title":"Longitudinal quality of life assessment after laparoscopic colorectal cancer surgery using the Gastrointestinal Quality of Life Index questionnaire: A multicentre prospective study","authors":"Tae-Gyun Lee, Seung-Bum Ryoo, Heung-Kwon Oh, Yong Beom Cho, Chang Hyun Kim, Ju Hyun Lee, Hong-Min Ahn, Hye-Rim Shin, Mi Jeong Choi, Min Hyeong Jo, Duck-Woo Kim, Sung-Bum Kang","doi":"10.1111/codi.70060","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of this study was to validate the Gastrointestinal Quality of Life Index (GIQLI) and assess its effectiveness in measuring changes in postoperative quality of life (QOL) after laparoscopic colorectal cancer surgery, including factors affecting early QOL impairment.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>This multicentre prospective study enrolled patients who underwent laparoscopic colorectal cancer surgery between November 2021 and February 2023. Participants completed the GIQLI and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Colorectal Cancer (EORTC QLQ-CR29) questionnaires preoperatively and at 1 and 3 weeks, 6 months and 1 year postoperatively. We evaluated GIQLI reliability, identified risk factors associated with early postoperative QOL impairment and assessed longitudinal changes in QOL to determine the timing of postoperative recovery.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The GIQLI showed high reliability, with a preoperative intraclass correlation coefficient of 0.930 (95% CI 0.899–0.951) and Cronbach alpha values >0.9 at all time points. The mean global GIQLI score decreased from 106.2 ± 14.7 preoperatively to 92.7 ± 15.2 at 1 week postoperatively (<i>p</i> < 0.001), recovered to 104.6 ± 13.8 at 6 months postoperatively (versus preoperatively, <i>p</i> > 0.99) and increased to 113.4 ± 13.3 at 1 year postoperatively (versus preoperatively, <i>p</i> < 0.001). Early T-stage (T1–2; OR 2.82, 95% CI 1.25–6.40, <i>p</i> = 0.013) and intra-abdominal drain use (OR 3.95, 95% CI 1.09–14.28, <i>p</i> = 0.036) were significant risk factors for substantial impairment of QOL at 1 week postoperatively. The predicted recovery period to 95% of preoperative QOL was 6.4 weeks (95% CI 6.00–8.30 weeks).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The GIQLI reliably assessed longitudinal changes in QOL after laparoscopic colorectal cancer surgery and demonstrated QOL recovery within 2 months postoperatively, providing guidance for patient counselling and optimizing postoperative care.</p>\n </section>\n </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 3","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colorectal Disease","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/codi.70060","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

The aim of this study was to validate the Gastrointestinal Quality of Life Index (GIQLI) and assess its effectiveness in measuring changes in postoperative quality of life (QOL) after laparoscopic colorectal cancer surgery, including factors affecting early QOL impairment.

Method

This multicentre prospective study enrolled patients who underwent laparoscopic colorectal cancer surgery between November 2021 and February 2023. Participants completed the GIQLI and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Colorectal Cancer (EORTC QLQ-CR29) questionnaires preoperatively and at 1 and 3 weeks, 6 months and 1 year postoperatively. We evaluated GIQLI reliability, identified risk factors associated with early postoperative QOL impairment and assessed longitudinal changes in QOL to determine the timing of postoperative recovery.

Results

The GIQLI showed high reliability, with a preoperative intraclass correlation coefficient of 0.930 (95% CI 0.899–0.951) and Cronbach alpha values >0.9 at all time points. The mean global GIQLI score decreased from 106.2 ± 14.7 preoperatively to 92.7 ± 15.2 at 1 week postoperatively (p < 0.001), recovered to 104.6 ± 13.8 at 6 months postoperatively (versus preoperatively, p > 0.99) and increased to 113.4 ± 13.3 at 1 year postoperatively (versus preoperatively, p < 0.001). Early T-stage (T1–2; OR 2.82, 95% CI 1.25–6.40, p = 0.013) and intra-abdominal drain use (OR 3.95, 95% CI 1.09–14.28, p = 0.036) were significant risk factors for substantial impairment of QOL at 1 week postoperatively. The predicted recovery period to 95% of preoperative QOL was 6.4 weeks (95% CI 6.00–8.30 weeks).

Conclusion

The GIQLI reliably assessed longitudinal changes in QOL after laparoscopic colorectal cancer surgery and demonstrated QOL recovery within 2 months postoperatively, providing guidance for patient counselling and optimizing postoperative care.

查看原文本刊更多论文

使用胃肠生活质量指数问卷对腹腔镜结直肠癌手术后的纵向生活质量进行评估：一项多中心前瞻性研究。

目的：本研究的目的是验证胃肠道生活质量指数（GIQLI），并评估其在衡量腹腔镜结直肠癌术后生活质量（QOL）变化的有效性，包括影响早期生活质量损害的因素。方法：这项多中心前瞻性研究纳入了2021年11月至2023年2月期间接受腹腔镜结直肠癌手术的患者。参与者在术前、术后1周、3周、6个月和1年分别完成GIQLI和欧洲癌症研究与治疗组织结直肠癌生活质量问卷（EORTC QLQ-CR29）。我们评估了GIQLI的可靠性，确定了与术后早期生活质量损害相关的危险因素，并评估了生活质量的纵向变化，以确定术后恢复的时间。结果：GIQLI具有较高的信度，术前类内相关系数为0.930 (95% CI 0.899 ~ 0.951)，各时间点的Cronbach alpha值为>0.9。总体平均GIQLI评分从术前的106.2±14.7分下降到术后1周的92.7±15.2分（p 0.99），术后1年上升到113.4±13.3分（与术前相比，p）。结论：GIQLI可靠地评估了腹腔镜结直肠癌手术后生活质量的纵向变化，显示了术后2个月内生活质量的恢复，为患者咨询和优化术后护理提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Colorectal Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

11.80%

发文量

406

审稿时长

1.5 months

期刊介绍： Diseases of the colon and rectum are common and offer a number of exciting challenges. Clinical, diagnostic and basic science research is expanding rapidly. There is increasing demand from purchasers of health care and patients for clinicians to keep abreast of the latest research and developments, and to translate these into routine practice. Technological advances in diagnosis, surgical technique, new pharmaceuticals, molecular genetics and other basic sciences have transformed many aspects of how these diseases are managed. Such progress will accelerate. Colorectal Disease offers a real benefit to subscribers and authors. It is first and foremost a vehicle for publishing original research relating to the demanding, rapidly expanding field of colorectal diseases. Essential for surgeons, pathologists, oncologists, gastroenterologists and health professionals caring for patients with a disease of the lower GI tract, Colorectal Disease furthers education and inter-professional development by including regular review articles and discussions of current controversies. Note that the journal does not usually accept paediatric surgical papers.