Leila Khalili, Gwoncheol Park, Ravinder Nagpal, Pradeep Bhide, Gloria Salazar
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引用次数: 0
Abstract
Background: Akkermansia muciniphila (A. muciniphila), a bacterial species within the human gut microbiome, has shown beneficial effects on host health. Emerging research suggests that A. muciniphila also influences neurobehavioral domains through the microbiota-gut-brain axis. This meta-analysis evaluates A. muciniphila's impact on depression, anxiety, and stress in mouse models.
Methods: We conducted a systematic search of PubMed, Science Direct, Embase, and Web of Science databases up to March 2024, identifying 15 eligible studies.
Results: Supplementation with A. muciniphila, its outer membrane protein (Amuc_1100), and extracellular vesicles (EVs) alleviated anxiety, depressive-like behaviors, and enhanced memory in mice. Compared to controls, intervention groups exhibited reduced anxiety-like behaviors, including increased travel distance in the open-field test (OFT) and more time spent in the lightbox during the light-dark box (LDB) test and open arms in the elevated plus maze (EPM). Depression-like symptoms were reduced, with lower immobility time in the tail suspension and forced swim tests. Memory function also improved, and learning time was reduced in the Y-maze and Barnes circular maze tests. Serotonin levels increased significantly in the serum and hippocampus, while corticosterone levels decreased, though not significantly. The intervention reduced hippocampal and serum inflammatory markers (TNFα, IL1β, IL6) and altered gut microbiome composition, increasing Akkermansia, Roseburia, Caldicoprobacter, and Lachnospiraceae.
Conclusion: This meta-analysis provides evidence supporting the health-promoting effects of A. muciniphila, one of the next-generation probiotics, in alleviating neuropsychiatric disorders. Given the high prevalence and clinical significance of depression, anxiety, and stress, further investigation into the therapeutic utility of A. muciniphila is warranted.
背景：嗜muciniphila （a.m uiniphila）是人类肠道微生物群中的一种细菌，对宿主健康有有益的影响。新兴的研究表明嗜粘杆菌也通过微生物-肠-脑轴影响神经行为领域。本荟萃分析在小鼠模型中评估嗜粘液单胞杆菌对抑郁、焦虑和应激的影响。方法：我们对PubMed、Science Direct、Embase和Web of Science数据库进行了系统检索，截止到2024年3月，确定了15项符合条件的研究。结果：补充嗜粘单胞杆菌及其外膜蛋白（Amuc_1100）和细胞外囊泡（EVs）可减轻小鼠的焦虑、抑郁样行为，并增强记忆。与对照组相比，干预组表现出更少的焦虑样行为，包括在开放场地测试（OFT）中增加的行走距离，在明暗箱（LDB）测试中在灯箱中花费的时间和在高架加迷宫（EPM）中张开双臂的时间。在悬尾和强迫游泳试验中，抑郁样症状减轻，静止时间缩短。在y形迷宫和巴恩斯圆形迷宫测试中，记忆功能也有所改善，学习时间缩短。血清和海马体中的血清素水平显著升高，而皮质酮水平下降，但不明显。干预降低了海马和血清炎症标志物（TNFα, il - 1β, il - 6），改变了肠道微生物组组成，增加了Akkermansia， Roseburia， caldicoprobter和Lachnospiraceae。结论：本荟萃分析支持新一代益生菌之一嗜muciniphila在缓解神经精神疾病方面的健康促进作用。鉴于抑郁、焦虑和压力的高患病率和临床意义，进一步研究嗜粘液芽胞杆菌的治疗效用是必要的。
期刊介绍：
Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience.
The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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