Regional difference on rotavirus vaccine coverage in children with diarrhea in Mozambique, before and during COVID-19 pandemic: a cross-sectional analysis.

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES
Marta Cassocera, Adilson Fernando Loforte Bauhofer, Assucênio Chissaque, Benilde Munlela, Esperança Guimarães, Telma Isaías, Carolina Conjo, Braiton Maculuve, Sérgio Chicumbe, Nilsa de Deus
{"title":"Regional difference on rotavirus vaccine coverage in children with diarrhea in Mozambique, before and during COVID-19 pandemic: a cross-sectional analysis.","authors":"Marta Cassocera, Adilson Fernando Loforte Bauhofer, Assucênio Chissaque, Benilde Munlela, Esperança Guimarães, Telma Isaías, Carolina Conjo, Braiton Maculuve, Sérgio Chicumbe, Nilsa de Deus","doi":"10.1186/s12879-025-10750-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Immunization coverage is a global concern for the Immunization Agenda 2030 due to the Coronavirus disease (COVID-19) pandemic. Prior to the pandemic, Mozambique had a positive impact on reducing all-cause diarrhea hospitalization and rotavirus positivity due to vaccination with the monovalent vaccine against rotavirus (Rotarix<sup>®</sup>). We evaluated rotavirus vaccine coverage in Mozambican children with diarrhea in four sentinel sites before and during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A cross-sectional analysis between January 2016 and April 2023 was performed using the National Diarrhea Surveillance data from four sentinel sites for children under five years old. The cut-off before and during the COVID-19 period was the date of the first COVID-19 case reported in Mozambique on March 22, 2020. Vaccination cards were used to verify rotavirus immunization status. A two-sample test for equality of proportions of rotavirus coverage before and during the COVID-19 pandemic was performed.</p><p><strong>Results: </strong>During the COVID-19 pandemic, the rotavirus vaccine coverage was 77.3% (133/172), significantly higher than the 68.6% (771/1124) before the pandemic [difference: 8.7% (95% CI: 1.6 to 15.9); p-value = 0.026]. The two sample test for equality of proportions indicates that at the sentinel site in Zambézia province in the center region of the country, the rotavirus vaccine coverage reduced significantly during the pandemic period compared to the pre COVID-19 pandemic period (difference: -28.1%; 95% CI: -47.8 to -8.3; p-value = 0.028).</p><p><strong>Conclusion: </strong>Despite national level increase of the rotavirus vaccine coverage, during the COVID-19 pandemic, there was a significant reduction in the sentinel site in the center region of the country. Future rotavirus interventions should target areas with lowest rotavirus vaccine coverage, also, rotavirus diarrheal cases and severity should be monitored in those settings to evaluate the interventions impact.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"382"},"PeriodicalIF":3.4000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924852/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12879-025-10750-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Immunization coverage is a global concern for the Immunization Agenda 2030 due to the Coronavirus disease (COVID-19) pandemic. Prior to the pandemic, Mozambique had a positive impact on reducing all-cause diarrhea hospitalization and rotavirus positivity due to vaccination with the monovalent vaccine against rotavirus (Rotarix®). We evaluated rotavirus vaccine coverage in Mozambican children with diarrhea in four sentinel sites before and during the COVID-19 pandemic.

Methods: A cross-sectional analysis between January 2016 and April 2023 was performed using the National Diarrhea Surveillance data from four sentinel sites for children under five years old. The cut-off before and during the COVID-19 period was the date of the first COVID-19 case reported in Mozambique on March 22, 2020. Vaccination cards were used to verify rotavirus immunization status. A two-sample test for equality of proportions of rotavirus coverage before and during the COVID-19 pandemic was performed.

Results: During the COVID-19 pandemic, the rotavirus vaccine coverage was 77.3% (133/172), significantly higher than the 68.6% (771/1124) before the pandemic [difference: 8.7% (95% CI: 1.6 to 15.9); p-value = 0.026]. The two sample test for equality of proportions indicates that at the sentinel site in Zambézia province in the center region of the country, the rotavirus vaccine coverage reduced significantly during the pandemic period compared to the pre COVID-19 pandemic period (difference: -28.1%; 95% CI: -47.8 to -8.3; p-value = 0.028).

Conclusion: Despite national level increase of the rotavirus vaccine coverage, during the COVID-19 pandemic, there was a significant reduction in the sentinel site in the center region of the country. Future rotavirus interventions should target areas with lowest rotavirus vaccine coverage, also, rotavirus diarrheal cases and severity should be monitored in those settings to evaluate the interventions impact.

在COVID-19大流行之前和期间,莫桑比克腹泻儿童轮状病毒疫苗覆盖率的区域差异:横断面分析
背景:由于冠状病毒病(COVID-19)大流行,免疫覆盖是2030年免疫议程关注的一个全球问题。在大流行之前,莫桑比克由于接种了轮状病毒单价疫苗(Rotarix®),在减少全因腹泻住院和轮状病毒阳性方面产生了积极影响。我们评估了在COVID-19大流行之前和期间四个哨点莫桑比克腹泻儿童的轮状病毒疫苗覆盖率。方法:对2016年1月至2023年4月期间来自4个5岁以下儿童监测点的国家腹泻监测数据进行横断面分析。2019冠状病毒病疫情之前和期间的截止日期为2020年3月22日,即莫桑比克报告首例COVID-19病例的日期。疫苗接种卡用于核实轮状病毒免疫状况。在COVID-19大流行之前和期间进行了轮状病毒覆盖率比例相等的双样本检验。结果:新冠肺炎大流行期间,轮状病毒疫苗接种率为77.3%(133/172),显著高于大流行前的68.6%(771/1124)[差异:8.7% (95% CI: 1.6 ~ 15.9);p值= 0.026]。两样本比例相等检验表明,与COVID-19大流行前相比,在该国中部赞比西亚省的哨点,轮状病毒疫苗覆盖率在大流行期间显著下降(差异:-28.1%;95% CI: -47.8 ~ -8.3;p值= 0.028)。结论:尽管在全国范围内轮状病毒疫苗覆盖率有所提高,但在2019冠状病毒病大流行期间,该国中部地区的哨点数量明显减少。未来的轮状病毒干预措施应针对轮状病毒疫苗覆盖率最低的地区,此外,应监测这些地区的轮状病毒腹泻病例和严重程度,以评估干预措施的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMC Infectious Diseases
BMC Infectious Diseases 医学-传染病学
CiteScore
6.50
自引率
0.00%
发文量
860
审稿时长
3.3 months
期刊介绍: BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信