Efficacy and safety of ketorolac and dexamethasone for preventing renal colic post stent removal: a randomized triple-blind, placebo-controlled clinical trial.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Annals of Medicine and Surgery Pub Date : 2025-02-11 eCollection Date: 2025-02-01 DOI:10.1097/MS9.0000000000002934
Shaghayegh Mahmoudiandehkordi, Reza Morovatshoar, Pedram Hadipour, Shahnaz Fooladi Sarabi, Mahta Fadaei, Abtin Ansari, Mohammad Farhadi-Shahi, Mohammadreza Noroozi
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引用次数: 0

Abstract

Background: Renal colic following stent removal post-ureteroscopy is a significant clinical issue. This study aims to evaluate the efficacy and safety of intramuscular ketorolac and dexamethasone in preventing renal colic after stent removal.

Methods: A randomized, triple-blind, placebo-controlled clinical trial was conducted with 147 patients. Participants were allocated to three groups: ketorolac only, ketorolac plus dexamethasone, and placebo. The primary outcome was the visual analog scale (VAS) score for pain, assessed at 1- and 7-days post-stent removal. Secondary outcomes included opioid use, emergency department visits, renal colic symptoms, and missed workdays.

Results: The combination group (ketorolac and dexamethasone) demonstrated significantly lower VAS scores at 24 hours compared to the placebo group (2.95 vs. 4.30, P = 0.008). Additionally, this group had fewer emergency department visits (2.0% vs. 22.4%, P = 0.010) and lower incidences of subjective renal colic (2.0% vs. 20.4%, P = 0.017). No significant differences were observed at 7 days post-stent removal.

Conclusion: Intramuscular ketorolac and dexamethasone significantly reduce pain and related complications following stent removal, providing an effective alternative to opioid analgesics.

酮罗拉酸和地塞米松预防支架移除后肾绞痛的有效性和安全性:一项随机、三盲、安慰剂对照的临床试验
背景:输尿管镜术后支架取出后肾绞痛是一个重要的临床问题。本研究旨在评价肌内注射酮罗拉酸和地塞米松预防支架取出后肾绞痛的疗效和安全性。方法:对147例患者进行随机、三盲、安慰剂对照临床试验。参与者被分为三组:仅使用酮罗拉酸、酮罗拉酸加地塞米松和安慰剂。主要结果是视觉模拟评分(VAS)疼痛评分,在支架移除后1天和7天进行评估。次要结局包括阿片类药物使用、急诊科就诊、肾绞痛症状和错过工作日。结果:与安慰剂组相比,联合用药组(酮洛拉克和地塞米松)在24小时VAS评分显著降低(2.95比4.30,P = 0.008)。此外,该组急诊科就诊次数较少(2.0%比22.4%,P = 0.010),主观肾绞痛发生率较低(2.0%比20.4%,P = 0.017)。在支架取出后7天没有观察到显著差异。结论:肌内注射酮乐酸和地塞米松可显著减轻支架取出后的疼痛和相关并发症,是阿片类镇痛药的有效替代。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Medicine and Surgery
Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-
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5.90%
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