Essential information about nanotechnology in cardiology.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Annals of Medicine and Surgery Pub Date : 2025-01-31 eCollection Date: 2025-02-01 DOI:10.1097/MS9.0000000000002867
Chukwuka Elendu, Dependable C Amaechi, Tochi C Elendu, Emmanuel C Amaechi, Ijeoma D Elendu, Janet C Omeludike, Eunice K Omeludike, Nwamaka C Onubogu, Emmanuel C Ogelle, Oluwatobi O M Meduoye, Praise O Oloyede, Chiamaka P Ezeh, Ikpembhosa J Esangbedo, Augustina C Adigwe, Nnachi M Akuma, Silas U Okafor
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Abstract

Cardiology, as a medical specialty, addresses cardiovascular diseases (CVDs), a leading cause of global mortality. Nanomaterials offer transformative potential across key areas such as drug delivery, stem cell therapy, imaging, and gene delivery. Nanomaterials improve solubility, bioavailability, and targeted delivery in drug delivery, reducing systemic side effects. Examples include gas microbubbles, liposomal preparations, and paramagnetic nanoparticles, which show promise in treating atherosclerosis. Stem cell therapy benefits from nanotechnology through enhanced cell culture conditions and three-dimensional scaffolds that support cardiomyocyte growth and survival. Gold nanoparticles and poly(lactic-co-glycolic acid)-derived microparticles further improve stem cell viability. In imaging, nanomaterials enable advanced visualization techniques such as magnetic resonance imaging with direct labeling and optical tracking via dye-conjugated nanoparticles. In gene delivery, polymeric nanocarriers like polyethyleneimine, dendrimers, and graphene-based materials offer efficient, non-viral alternatives, with magnetic nanoparticles showing promise in targeted applications. Ongoing research highlights the potential of nanomaterials to revolutionize CVD management by improving therapeutic outcomes and enabling precision medicine. These advancements position nanotechnology as a cornerstone of modern cardiology.

关于纳米技术在心脏病学中的基本信息。
心脏病学作为一门医学专业,研究全球死亡的主要原因——心血管疾病。纳米材料在药物传递、干细胞治疗、成像和基因传递等关键领域提供了变革潜力。纳米材料提高了药物的溶解度、生物利用度和靶向递送,减少了全身副作用。例子包括气体微泡、脂质体制剂和顺磁性纳米颗粒,它们在治疗动脉粥样硬化方面显示出希望。干细胞治疗受益于纳米技术,通过增强细胞培养条件和支持心肌细胞生长和存活的三维支架。金纳米粒子和聚乳酸-羟基乙酸衍生的微粒子进一步提高了干细胞的活力。在成像方面,纳米材料实现了先进的可视化技术,如通过染料共轭纳米颗粒进行直接标记和光学跟踪的磁共振成像。在基因传递中,高分子纳米载体如聚乙烯亚胺、树状大分子和石墨烯基材料提供了高效、非病毒的替代品,磁性纳米颗粒在靶向应用中显示出前景。正在进行的研究强调了纳米材料通过改善治疗结果和实现精准医疗来彻底改变心血管疾病管理的潜力。这些进步将纳米技术定位为现代心脏病学的基石。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Medicine and Surgery
Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-
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5.90%
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1665
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