MXene Loaded with Cu(2-x)Se Nanozyme for Nanocatalytic Tumor Therapy.

Abstract

Traditional tumor treatments have certain limitations which have serious negative effects, such as the difficulty in cutting out tumors, the damage to normal tissues, and complications. Ordinary nanozymes generally have low catalytic activity and require higher doses for treatment, which can increase the  toxicity and side effects. Here, we designed a Cu(2-x)Se-loaded on MXene, which can catalyze the conversion of the overexpressed hydrogen peroxide into O2 and -OH in cancer cells by Cu(2-x)Se with the catalase (CAT)-like activity and peroxidase (POD) activity, which can effectively alleviate the tumor microenvironment (TEM) hypoxia, as well as degrading the overexpressed glutathione (GSH) and killing the tumor cells to a large extent. At the same time, we used Nanozyme-Carrier Interface Modulation (NCIM): by regulating the interface interaction between nanozymesand carrier materials , the catalytic activity of nanozymes and the photothermal performance of the support were optimized. This regulation can be achieved by adjusting the mass ratio of nanozymes to carriers, surface modification, etc. to improve the performance of the composites. Dual enzyme-active nanozymes loaded with MXene provide a way to synergies catalytic and photothermal therapies, which are considered to be promising materials for future development in the field of nanocomposites for disease treatment.