Relationships between hypometabolism and both β-amyloid and tau PET in corticobasal syndrome

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-03-20 DOI:10.1002/alz.70018

Alma Ghirelli, Austin W. Goodrich, Yehkyoung C. Stephens, Jonathan Graff-Radford, Farwa Ali, Mary M. Machulda, Chistopher G. Schwarz, Matthew L. Senjem, Federica Agosta, Massimo Filippi, Clifford R. Jack Jr., Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell

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引用次数: 0

Abstract

INTRODUCTION

Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%–50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete.

METHODS

Thirty-three CBS patients and 45 controls underwent fluorodeoxyglucose (FDG), flortaucipir, and Pittsburgh compound-B PET and were classified as A± and T±. FDG-PET uptake was extracted for 12 regions-of-interest in dominant (most affected) and non-dominant hemispheres and compared across A/T groups.

RESULTS

A+T+ patients had greater hypometabolism in temporo-parieto-occipital cortices than A+T- and A-T- groups, with no differences observed between the A+T- and A-T- groups. FDG asymmetry was more accentuated in A+T+ patients. Medial temporal and basal ganglia metabolism were similar across AT groups.

DISCUSSION

Amyloid and tau positivity contribute synergistically to hypometabolism and asymmetry in temporo-parieto-occipital cortices in CBS, with AD-like patterns of hypometabolism observed only in A+T+ patients.

Highlights

Amyloid (A) and tau PET (T) status can be used to stratify CBS patients.
A+T+ CBS patients show more hypometabolism in temporo-parieto-occipital cortices.
Medial temporal metabolism (typical AD pattern) is similar across AT groups.
Parieto-occipital cortices should be assessed when investigating AT pathology in CBS.
Amyloid and tau positivity contribute synergistically to hypometabolism and asymmetry in CBS.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.