Alma Ghirelli, Austin W. Goodrich, Yehkyoung C. Stephens, Jonathan Graff-Radford, Farwa Ali, Mary M. Machulda, Chistopher G. Schwarz, Matthew L. Senjem, Federica Agosta, Massimo Filippi, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell
{"title":"Relationships between hypometabolism and both β-amyloid and tau PET in corticobasal syndrome","authors":"Alma Ghirelli, Austin W. Goodrich, Yehkyoung C. Stephens, Jonathan Graff-Radford, Farwa Ali, Mary M. Machulda, Chistopher G. Schwarz, Matthew L. Senjem, Federica Agosta, Massimo Filippi, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell","doi":"10.1002/alz.70018","DOIUrl":null,"url":null,"abstract":"Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%–50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"14 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.70018","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%–50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete.
期刊介绍:
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.