Coumarin-based fluorescent probe for hypochlorite detection and imaging of acute kidney injury

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2025-03-19 DOI:10.1016/j.snb.2025.137645

Ying-Ying Kong , Bo Liu , Yu-Hang Zhang , Di Han , Hong-Kun Yang , Jun-Tang Lin , Hong-Cheng Xia

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Abstract

Acute kidney injury (AKI) has attracted attention as a frequent clinical disease, and the occurrence of AKI can lead to the decline of kidney function and even endanger life. Realizing early diagnosis of AKI can effectively control and treat the condition. Current clinical diagnostic methods cannot meet the accurate diagnosis of early acute kidney injury. Oxidative stress has been proved to be a causative factor of AKI. Therefore, we constructed a fluorescent probe based on coumarin fluorophore for the detection of hypochlorite (HClO) produced during oxidative stress to realize early diagnosis of AKI. The structure of the probe is simple and easy to synthesize, and it has the ability of colorimetric and fluorescence recognition for HClO. The probe responds to HClO as fast as 3 seconds and shows good selectivity and sensitivity to HClO with a detection limit of 15.6 nM. The probe is also well used for imaging exogenous and endogenous HClO in cells. It also can be successfully used for imaging and diagnosis of cisplatin-induced acute kidney injury.

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.