An insight into Synthetic, Structural and Medicinal perspective of imidazole analogs: A review

Abstract

Imidazole is a versatile heterocyclic moiety that has been found to be widely present in many natural and synthetic molecules. It is a ubiquitous moiety that has been widely explored by the scientific community owing to its broad spectrum of biological activities. To pave the way for future research, a comprehensive study on the imidazole moiety was carried out. This review paper will assist researchers and academics in developing more therapeutically active imidazole-based compounds. Herein, we provide a thorough overview of the current research status of imidazole-based compounds with a wide variety of biological activities, including antiviral, anti-cancer, anti-microbial, analgesic and anti-inflammatory, antidiabetic, antiprotozoal, antipsychotic, anti-aging, antioxidant, and anthelmintic. Through this review article, our focus is to contribute towards the recent advancements in the synthetic methodologies and SAR study of imidazoles that contribute as a useful class of heterocyclic compounds involved in the development of therapeutically active molecules. We sincerely hope that this review will serve as a pertinent guide for imminent research in the development of imidazoles and their derivatives.